1998-2020年北京市东城区50岁及以上HIV/AIDS病人生存时间及影响因素分析  

Survival time and influencing factors of HIV/AIDS patients aged 50 and above in Dongcheng district of Beijing,1998-2020

作　　者：田飞[1] 高颂[1] 李铮 王颖慧 TIAN Fei;GAO Song;LI Zheng;WANG Ying-hui(Dongcheng District Center for Disease Prevention and Control,Beijing 100050,China)

机构地区：[1]北京市东城区疾病预防控制中心,100050

出　　处：《首都公共卫生》2022年第4期229-232,共4页Capital Journal of Public Health

摘　　要：目的了解北京市东城区确诊时年龄在50岁及以上艾滋病病毒(human immunodeficiency virus,HIV)感染者/艾滋病(acquired immune deficiency syndrome,AIDS)病人(简称HIV/AIDS病人)生存时间及影响因素。方法采用回顾性队列研究方法,在中国艾滋病综合防治信息系统中收集1998-2020年北京市东城区确诊时年龄为50岁及以上的HIV/AIDS病人信息,使用寿命表法分析累积生存率。利用Kaplan-Meier法计算平均生存时间;利用竞争风险模型分析研究对象生存时间的影响因素。结果270例HIV/AIDS病人中,14例死于艾滋病及相关疾病,东城区50岁及以上的HIV/AIDS病人诊断后1、2和5年的累积生存率分别为95.24%、94.66%和92.83%,竞争风险模型分析结果显示:确诊时疾病状态为艾滋病病人(SHR=8.008,95%CI:1.698~37.777,P=0.009)、未进行抗病毒治疗(SHR=15.990,95%CI:4.401~58.092,P<0.001)是减少生存时间的危险因素。结论北京市东城区确诊时年龄在50岁及以上的HIV/AIDS病人中,接受抗病毒治疗、确诊时疾病状态为HIV感染者的HIV/AIDS病人生存时间较长。今后工作中应提高筛查力度,尽可能早期发现HIV感染者和开展治疗,以提高其诊断后生存质量和生存时间。Objective To investigate the survival time and influencing factors of HIV/AIDS patients aged 50 and above at the time of diagnosis in Dongcheng district,Beijing.Methods A retrospective cohort study was conducted to collect the information of HIV/AIDS patients aged 50 years or older at diagnosis in Dongcheng district of Beijing from 1998 to 2020 from the China Integrated AIDS Prevention and Control Information System.Cumulative survival rates were analyzed by life table method.Kaplan-meier method was used to calculate the mean survival time.Competitive risk model was used to analyze the factors influencing the survival time of the research object.Results Among 270 HIV/AIDS patients,14 died of AIDS and related diseases.The cumulative survival rates of HIV/AIDS patients aged 50 and above in Dongcheng district were 95.24%,94.66%and 92.83%at 1,2 and 5 years after diagnosis,respectively.The analysis result of competitive risk model showed that having AIDS at diagnosis(SHR=8.008,95%CI:1.698-37.777,P=0.009)and not receiving antiviral therapy(SHR=15.990,95%CI:4.401-58.092,P<0.001)were risk factors for increased mortality.Conclusions Among HIV/AIDS patients aged 50 and above at the time of diagnosis in Dongcheng district,Beijing,HIV/AIDS patients who received antiviral therapy,and whose disease status at the time of diagnosis were HIV infected had a longer survival time.In the future,screening efforts should be enhanced to detect HIV infection as early as possible and carry out treatment to improve the quality of life and survival time after diagnosis.

关 键 词：艾滋病 回顾性分析 生存分析 影响因素 

分 类 号：R512.91[医药卫生—内科学]