结核免疫应答相关白细胞介素的作用机制研究进展  

Regulation of interleukins on anti-tuberculosis immune response of lymphocytes

作　　者：刘曦 沈洪波 王菲菲[3] 徐军发 LIU Xi;SHEN Hongbo;WANG Feifei;XU Junfa(Department of Clinical Immunology,Institute of Clinical Laboratory Medicine,Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics,Guangdong Medical University,Dongguan 523808,Guangdong Province,China;Clinic and Research Center of Tuberculosis,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,China;Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS),and Department of Microbiology and Parasitology,School of Basic Medical Sciences,Shanghai Medical College,Fudan University,Shanghai 200032,China)

机构地区：[1]广东医科大学检验医学研究所临床免疫学研究室,广东东莞523808 [2]同济大学附属上海市肺科医院结核病临床研究中心,上海200433 [3]复旦大学上海医学院基础医学院病原生物学系,教育部、卫健委、医科院医学分子病毒学重点实验室,上海200032

出　　处：《微生物与感染》2022年第1期41-46,共6页Journal of Microbes and Infections

基　　金：“十三五”传染病重大专项(2018ZX10731301-006-001);国家自然科学基金(81870016);上海市自然科学基金(20ZR1406200)。

摘　　要：白细胞介素(简称白介素)能够调控免疫细胞的分化、增殖及效应功能。结核抗原特异性诱导的白介素的表达水平能够表征结核杆菌感染后的机体状态。在机体的抗结核免疫应答中,白介素可以直接调控吞噬细胞对胞内感染结核杆菌的杀菌活性;也能够调控效应性T细胞的增殖,并进一步激活吞噬细胞的杀菌功能。目前,部分白介素已被证明有望用于结核病的免疫辅助治疗,正在进行相关临床实验。本文对白介素调控免疫细胞抗结核免疫应答的研究进展进行综述,以期为制定结核病的白介素免疫辅助治疗方案提供指导。Cytokines of interleukins(IL)can regulate the differentiation,proliferation and effector function of immune cells.The expression of specific interleukins induced by Mycobacterium tuberculosis(Mtb)antigens could be used to characterize Mtb infection in humans.In host’s anti-tuberculosis immune defense,interleukins can directly regulate the bactericidal activity of phagocytes to inhibit intracellular Mtb growth.Interleukins can also induce the proliferation and effect function of T cells to further enhance the bactericidal activity of phagocytes.Some interleukins are being tested in clinical trials as an adjuvant immunotherapy for tuberculosis treatment.Here,this study reviewed the latest research progresses of interleukins regulating anti-tuberculosis immune response of lymphocytes,and discussed the rationale for the development of interleukins as potential adjunctive treatment in tuberculosis.

关 键 词：白细胞介素 抗结核免疫 结核病辅助治疗 

分 类 号：R378.911[医药卫生—病原生物学] R392[医药卫生—基础医学]