氯己定擦浴预防ICU患者多重耐药菌感染的Meta分析  

Sponge the body with Chlorhexidine to prevent multidrug-resistant organismsinduced infections in critically patients:a Meta analysis

作　　者：张婷婷[1] 花云[1] Zhang Tingting;Hua Yun(Affiliated hospital of Nantong University,Nantong,Jiangsu,226000,China)

机构地区：[1]南通大学附属医院,江苏南通226000

出　　处：《齐齐哈尔医学院学报》2022年第13期1292-1297,共6页Journal of Qiqihar Medical University

摘　　要：目的评价为ICU患者氯己定擦浴对多重耐药菌感染的预防效果。方法对Pubmed、Ovid Medline、Cochroane、Embase、中国知网(CNKI)、中国生物医学文献数据服务系统(CBM)、维普数据库(VIP)及万方数据库(Wan Fang Data)中有关于氯己定擦浴或者洗浴预防ICU患者多重耐药菌感染的临床对照试验和随机对照试验进行检索,检索时间均为从建库开始至2020年07月。由2名研究者分别进行文献检索、文献筛选、提取数据以及评价纳入的文献质量,最后使用Review Manager 5.3软件对相关的数据进行分析。结果最终纳入10项研究,包括7篇英文和3篇中文,其中6篇为临床对照研究、4篇为随机对照研究。Meta结果显示氯己定全身擦浴能够降低ICU患者多重耐药菌感染的发生率,差异具有统计学的意义(RR=0.54,95%CI:0.44-0.66,P<0.001)。结论氯己定全身擦浴能够降低ICU患者多重耐药菌的发生率,可以临床推广。Objective To review the influence of sponge bathing with chlorhexidine on preventing multidrug-resistant organismsinduced infections in critically patients.Methods Search the articles which the content about sponge the body with chlorhexidine in preventing multidrugresistant organisms induced infections from digital databases of Pubmed,Ovid Medline,Cochrane,Embase,Chinese National Knowledge Infrastructure(CNKI),China Biomcdical Litcrature Database(CBM),Viper database(VIP),and WanFang Data.The literature contained clinical control studies and randomized controlled trails,and the literatures were published since the database was established until July 2020.Two researchers independentlycarried out literature search and select the potentially eligible articles,extracted the data,and assessed risk of bias.Review Manager5.3 software was used to perform Meta-analysis and sub-group analysis.Results Ten published studies were included for Meta-analysis,which contained 4 RCTs and 6 CCTs.The results of Meta-analysis showed that body bathing with chlorhexidine had decreased the incidence of multidrug-resistant organisms infections in critically ill patients(RR=0.54,95%CI:0.44-0.66,P<0.001).Conclusions Chlorhexidine body sponge bathing could reduce the multidrug-resistant organisms infections in critically ill patients.It is worth popularizing in clinical work.

关 键 词：氯己定 擦浴 感染 多重耐药菌 ICU META分析 

分 类 号：R446.5[医药卫生—诊断学]