不同给药途径主动免疫联合低分子肝素治疗在复发性自然流产的应用价值  

Clinical value of active immunity to different routes of administration combined with low molecular weight heparin in the treatment of recurrent spontaneous abortion

作　　者：谢欢宇 陈其霞[1] 赵金菊[1] XIE Huan-yu;CHEN Qi-xia;ZHAO Jin-ju(Department of Obstetrics and Gynecology,Xichang People's Hospital,Xichang 615000,China)

机构地区：[1]西昌市人民医院妇产科,四川凉山615000

出　　处：《中国处方药》2022年第8期129-132,共4页Journal of China Prescription Drug

摘　　要：目的探究不同给药途径主动免疫联合低分子肝素治疗在复发性自然流产的应用价值。方法选取2018年11月~2021年11月纳入的65例复发性自然流产患者,按照简单随机数字表法分为对照组(n=32)和观察组(n=33),其中对照组给予皮内注射进行主动免疫联合低分子肝素治疗,观察组给予皮下注射进行主动免疫联合低分子肝素治疗。评估两组临床疗效、注射疼痛程度、卵巢超声血流动力学[收缩期峰值流速(PSV)、舒张末期流速(EDV)、阻力指数(RI)、搏动指数(PI)]、再次妊娠成功率、治疗满意度。结果观察组患者治疗总有效率为96.97%,显著高于对照组的81.25%(P<0.05);观察组患者注射疼痛评分为(2.66±0.73),显著低于对照组患者注射疼痛评分(4.35±1.31),差异具有统计学意义(t=6.397,P<0.05);治疗后,两组患者卵巢超声血流动力学中收缩期峰值流速(PSV)、舒张末期流速(EDV)、阻力指数(RI)、搏动指数(PI)相比较无明显差异,差异无统计学意义(P>0.05);治疗后,观察组患者再次妊娠成功率为93.94%(31/33),对照组患者再次妊娠成功率为93.75%(30/32),两组患者再次妊娠成功率差异无统计学意义(χ^(2)=0.001,P=0.975>0.05);治疗后,观察组患者治疗满意度为96.97%,显著高于对照组的68.75%(P<0.05)。结论与皮内注射进行主动免疫联合低分子肝素治疗复发性自然流产患者相比,皮下注射进行主动免疫联合低分子肝素治疗复发性自然流产患者疗效更显著,更能减轻患者的注射疼痛程度,且患者治疗满意度更高。Objective To explore the value of active immunity to different routes of administration combined with low molecular weight heparin in the treatment of recurrent spontaneous abortion.Methods 65 patients with recurrent spontaneous abortion in our hospital from November 2018 to November 2021 were selected and divided into control group(n=32)and observation group(n=33)according to simple random number table method.The control group was given intradermal injection of active immunization combined with low molecular weight heparin.The observation group was treated with subcutaneous injection of active immunity combined with low molecular weight heparin.The clinical efficacy,injection pain degree,ovarian ultrasonic hemodynamics[peak systolic flow rate(PSV),end diastolic flow rate(EDV),resistance index(RI),pulsatile index(PI)],success rate of second pregnancy and treatment satisfaction were evaluated in both groups.Results The total effective rate in observation group was 96.97%,significantly higher than 81.25% in control group(P<0.05).Injection pain score of observation group was(2.66±0.73),which was significantly lower than that of control group(4.35±1.31),and the difference was statistically significant(t=6.397,P<0.05).After treatment,there were no significant differences in the peak systolic flow rate(PSV),end diastolic flow rate(EDV),resistance index(RI)and pulsatile index(PI)in ovarian ultrasound hemodynamics between 2 groups(P>0.05).After treatment,the success rate of repregnancy was 93.94.00%(31/33)in the observation group and 93.75%(30/32)in the control group,and there was no significant difference between the two groups(χ^(2)=0.001,P=0.975>0.05).After treatment,the satisfaction degree of observation group was 96.97%,which was significantly higher than that of control group(68.75%,P<0.05).Conclusion Compared with intradermal injection of active immunization combined with low molecular weight heparin in the treatment of recurrent spontaneous abortion patients,subcutaneous injection of active immunization combin

关 键 词：不同给药途径主动免疫 皮内注射 皮下注射 复发性自然流产 低分子肝素 卵巢超声血流动力学 

分 类 号：R714.21[医药卫生—妇产科学]