益肾活血方对腹膜透析患者腹透液转化生长因子β_(1)和结缔组织生长因子干预研究  

Research on the intervention of Yishen Huoxue Recipe on transforming growth factor β_(1),connective tissue growth factor in peritoneal dialysis patients

作　　者：张璐 马凯玲 ZHANG Lu;MA Kai-ling(Shanxi Hospital of Integrated Traditional Chinese and Western Medicine,Taiyuan 030000,China)

机构地区：[1]山西省中西医结合医院,太原030000

出　　处：《中国处方药》2022年第8期159-162,共4页Journal of China Prescription Drug

基　　金：山西省中医药管理局科研课题(2019ZYYC034);山西中医药大学2020年度科技创新能力培育计划中医学术流派传承工作室建设项目(2020PY-LP-10)。

摘　　要：目的探讨益肾活血方对腹膜透析患者腹透液转化生长因子(TGF-β_(1))、结缔组织生长因子(connective tissue growth factor,CTGF)等指标的影响,为该方的应用提供可靠的理论及循证医学证据。方法选取2020年1月~2021年6月就诊于山西中医药大学附属中西医结合医院肾内二科门诊及住院患者且符合纳入标准者40例,随机分为对照组及治疗组各20例,对照组采用西医常规治疗,治疗组在西医常规治疗基础上,加用益肾活血方进行治疗。分别于治疗0 d、2周、4周及8周时,测定血肌酐(SCr),尿素氮(BUN)、24 h尿量、腹膜透析液TGF-β_(1)、CTGF水平,进行统计学对比分析。结果治疗组患者血肌酐及尿素氮水平降低,但与治疗前比较差异无统计学意义(P>0.05);治疗后两组组间比较差异无统计学意义(P>0.05)。治疗后两组患者腹透液TGF-β_(1)、CTGF水平均升高,治疗前后组内比较,差异具有统计学意义(P<0.05);治疗后组间比较,治疗组治疗4周、8周较同时期对照组水平低,且差异具有统计学意义(P<0.05)。结论随着治疗时间延长,治疗组与对照组患者腹透液TGF-β_(1)、CTGF水平均升高,表明TGF-β_(1)、CTGF参与腹膜纤维化的进程;益肾活血方基于降低腹透液TGF-β_(1)、CTGF水平,阻断炎症因子的表达,抗腹膜纤维化。Objective To investigate the effects of Yishen Huoxue Recipe on transforming growth factorβ_(1)(TGF-β_(1)),connective tissue growth factor(CTGF)and other indicators of peritoneal dialysis patients,and provide a reliable theory for its application and evidence-based medicine.Methods From January 2020 to June 2021,40 outpatients and inpatients in the Second Department of Nephrology of the Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Shanxi University of Traditional Chinese Medicine were selected and met the inclusion criteria.They were randomly divided into control group and treatment group with 20 each,the control group treated with conventional Western medicine,and the treatment group treated with Yishen Huoxue Decoction on the basis of conventional Western medicine treatment.The serum creatinine(SCr),urea nitrogen(BUN),24h urine output,peritoneal dialysate TGF-β_(1) and CTGF levels were measured at 0 days,2 weeks,4 weeks,and 8 weeks of treatment,and statistical analysis was performed.Results The serum creatinine and urea nitrogen levels of patients in the treatment group decreased,but there was no statistically significant difference compared with before treatment(P>0.05);there was no statistically significant difference between the two groups after treatment(P>0.05).After treatment,The levels of TGF-β_(1) and CTGF in the peritoneal dialysis fluid of the patients in the two groups increased,and the difference was statistically significant between the groups before and after treatment(P<0.05);After the treatment,the treatment group was treated for 4 weeks and 8 weeks compared with the control in the same period.The level of TGF-β_(1) and CTGF was lower in the treatment group with statistically significant(P<0.05).Conclusion As the treatment time is extended,the levels of TGF-β_(1) and CTGF in the peritoneal dialysate of patients in the treatment group and the control group increased,indicating that TGF-β_(1) and CTGF were involved the process of peritoneal fibrosis;Yishen H

关 键 词：益肾活血方 腹膜透析 腹膜纤维化 转化生长因子β_(1) 结缔组织生长因子 

分 类 号：R285.6[医药卫生—中药学]