抗原特异性HLA-E限制性CD8^(+)T细胞在感染性疾病中的作用  

Functions of HLA-E-restricted epitope-specific CD8^(+)T cells in infectious diseases

作　　者：李昕瑜 马樱 唐康 刘晓斌[1] 陈丽华 LI Xin-yu;MA Ying;TANG Kang;LIU Xiao-bin;CHEN Li-hua(Department of Immunology,Medical College of Yan'an University,Yan'an 716000,China;Department of Immunology,School of Basic Medicine,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]延安大学医学院免疫学教研室,延安716000 [2]空军军医大学基础医学院免疫学教研室,西安710032

出　　处：《现代免疫学》2022年第4期344-348,353,共6页Current Immunology

基　　金：国家自然科学基金面上项目(81871239,82071848);国家自然科学基金青年项目(81901600)。

摘　　要：HLA-E是非经典的HLAⅠ类分子中的重要成员之一。在免疫系统中,HLA-E不仅可以作为NK细胞和CD8^(+)T细胞表面CD94和NKG2A/C的配体介导细胞生物学功能,而且可以提呈抗原表位给CD8^(+)T细胞的TCR识别,介导CD8^(+)T细胞应答。HLA-E可结合来自病原体、肿瘤以及自身抗原等的多种抗原表位,并将其提呈给CD8^(+)T细胞,通过与CD8^(+)T细胞上的不同受体相互作用介导不同的免疫效应。在感染性疾病中,HLA-E可提呈病原体来源的抗原表位给CD8^(+)T细胞的TCR特异性识别,激活CD8^(+)T细胞,增强适应性免疫应答。因此,HLA-E限制性CD8^(+)T细胞是免疫应答过程中的一个重要参与者。该文对HLA-E限制性CD8^(+)T细胞在感染性疾病中的作用及机制进行综述。HLA-E is one of the important nonclassical HLA-Ⅰmolecules.In immune system,HLA-E not only mediates cell biological functions as a ligand of CD94 and NKG2 A/C on the surface of NK and CD8^(+)T cells,but also presents antigenicepitopes to the TCRs for recognition,which in turn activates CD8^(+)T cell responses.HLA-E binds a variety of antigenic epitopes from pathogens,tumors and self-antigens.It then presents them to CD8^(+)T cells by interacting with different receptors on CD8^(+)T cells to mediate different immune effects.In infectious diseases,HLA-E presents pathogen-derived epitopes to CD8^(+)T cells by binding to specific TCRs,thus elicits CD8^(+)T cell responses,which enhance the adaptive immune responses.Therefore,HLA-E-restricted CD8^(+)T cells play an important role in the process of immune responses.This article reviews the roles and mechanisms of HLA-E-restricted CD8^(+)T cells in infectious diseases.

关 键 词：人类白细胞抗原E CD8^(+) T细胞 感染性疾病 

分 类 号：R392.9[医药卫生—免疫学]