温度敏感性(PNIPAM)_(2)-b-HTPB-b-(PNIPAM)_(2)嵌段共聚物药物包覆与释放性能研究  

Study on drug coating and release properties of temperature sensitive(PNIPAM)2-b-HTPB-b-(PNIPAM)2 block copolymer

作　　者：张新建[1] 牛莉[1] 孙燕 王甫[1] ZHANG Xin-jian;NIU Li;SUN Yan;WANG Fu(Anhui Vocational College of Mechanical and Electrical Engineering,Wuhu 241002 China)

机构地区：[1]安徽机电职业技术学院航空与材料学院,安徽芜湖241002

出　　处：《新余学院学报》2022年第4期17-23,共7页Journal of Xinyu University

基　　金：安徽省教育厅科学研究重点项目“基于PNIPAM的温敏双亲性可降解智能高分子材料的自组装与性能研究”(KJ2021A1514)。

摘　　要：采用原子转移自由基聚合法合成了一种具有温敏双亲性的A_(2)BA_(2)型嵌段聚合物(PNIPAM)_(2)-b-HTPB-b-(PNIPAM)_(2),通过透射电子显微镜观测了其形态和尺寸。结果表明,在高于低临界溶解温度时,胶束形貌更规则、球形形貌更明显,且胶束尺寸变小,表现出亲-疏水微相分离行为。释放实验证明,嵌段共聚物胶束用于包覆抗癌药物紫杉醇(PTX),具有高达71.2%的药物包覆率。包覆PTX的胶束药物制剂在温度高于37℃时约有80%的PTX释放出来,表现出温度调制的药物释放行为。采用MTT法评价表明,制备的共聚物胶束将来可作为疏水药物载体,具有潜在的生物医学价值。A temperature sensitive amphiphilic A_(2)BA_(2)block polyme(PNIPAM)_(2)-b-HTPB-b-(PNIPAM)_(2),was synthesized by atom transfer radical polymerization(ATRP).Its morphology and size were observed by transmission electron microscopy(TEM).The results showed that above the low critical dissolution temperature(LCST),the micelle morphology was more regular,the spherical morphology was more obvious,and the micelle size became smaller,showing the behavior of hydrophilic-hydrophobic microphase separation.Release experiments showed that block copolymer micelles were used to coat anticancer drug paclitaxel(PTX),and the drug coating efficiency was as high as 71.2%.When the temperature was higher than 37℃,about 80%of PTX was released,showing a temperature modulated drug release behavior.The evaluation by MTT method shows that the copolymer micelles can be used as hydrophobic drug carriers in the future and have potential biomedical value.

关 键 词：原子转移自由基聚合 嵌段共聚物 胶束 药物释放 

分 类 号：R944[医药卫生—药剂学]