冻干重组人脑利钠肽治疗慢性心力衰竭的疗效  

Efficacy of Lyophilized Recombinant Human Brain Natriuretic Peptide in the Treatment of Chronic Heart Failure

作　　者：李建华[1] 白彩艳 陈莹恩 LI Jian-hua;BAI Cai-yan;CHEN Ying-en(The First Affiliated Hospital of Xinxiang Medical College,Henan Xinxiang 453100)

机构地区：[1]新乡医学院第一附属医院,河南新乡453100

出　　处：《深圳中西医结合杂志》2022年第8期74-77,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨冻干重组人脑利钠肽治疗慢性心力衰竭的疗效,并分析其作用机制。方法:选择2020年2月至2021年2月来新乡医学院第一附属医院接受诊治的108例慢性心力衰竭患者进行研究。采用双色球法将患者分为两组,各54例。对照组行常规治疗,观察组在对照组基础上加以冻干重组人脑利钠肽治疗。比较两组患者的临床疗效、心功能指标、可溶性生长刺激表达基因2蛋白(sST2)、半乳糖凝集素3(Gal-3)及不良反应发生率。结果:治疗后,观察组患者的总有效率为92.60%,高于对照组的77.78%,差异具有统计学意义(P<0.05);两组患者的心功能指标均较治疗前改善,观察组患者心房内径、左心室收缩末径及左心室舒张末径均低于对照组,差异均具有统计学意义(P<0.05);两组患者的sST2、Gal-3均低于治疗前,观察组患者sST2、Gal-3均低于对照组,差异均具有统计学意义(P<0.05)。两组患者治疗期间的不良反应发生率比较,差异无统计学意义(P>0.05)。结论:慢性心力衰竭患者在常规治疗的基础上加以冻干重组人脑利钠肽治疗,疗效较单纯常规治疗更好,其作用机制可能与冻干重组人脑利钠肽能改善心功能指标,降低sST2、Gal-3水平有关。Objective To investigate the efficacy of lyophilized recombinant human brain natriuretic peptide in the treatment of chronic heart failure and analyze its mechanism.Methods A total of 108 patients with chronic heart failure who were admitted to the First Affiliated Hospital of Xinxiang Medical College from February 2020 to February 2021 were selected for this study.The patients were divided into two groups with 54 cases in each group by double chromosphere method.The control group received routine treatment,and the observation group was treated with freeze-dried recombinant human brain natriuretic peptide on the basis of control group.Clinical efficacy,cardiac function indexes,soluble growth stimulation expresses the gene 2 protein(sST2),galactose agglutinin 3(Gal-3)and incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was 92.60%,higher than 77.78% of the control group,the difference was statistically significant(P<0.05);Cardiac function indexes in the two groups were improved compared with before treatment,and atrial inner diameter,left ventricular end-systolic diameter and left ventricular end-diastolic diameter in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).sST2 and Gal-3 in the two groups were lower than those before treatment,and sST2 and Gal-3 in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Chronic heart failure patients treated with freeze-dried recombinant human brain natriuretic peptide on the basis of conventional treatment have better curative effect than conventional treatment alone.Its mechanism of action may be related to that freeze-dried recombinant human brain natriuretic peptide can improve cardiac function indexes and reduce

关 键 词：慢性心力衰竭 冻干重组人脑利钠肽 生长刺激表达基因2蛋白 半乳糖凝集素3 

分 类 号：R541.6[医药卫生—心血管疾病]