聚合物胶束作为抗癌药物纳米递送载体的研究进展  

Research Progress of Polymer Micelles as Nano Delivery Carriers for Anticancer Drugs

作　　者：郭娜[1] 吕佳琦 李云 李媛 罗来龙 李明媛 GUO Na;LÜ Jiaqi;LI Yun;LI Yuan;LUO Lailong;LI Mingyuan(College of Biotechnology,Tianjin University of Science&Technology,Tianjin 300457,China;Zhongguancun Outpatient Department,Central Medical District of Chinese PLA General Hospital,Beijing 100089,China;Tianjin Enterprise Key Laboratory on Hyaluronic Acid Application Research,Tianjin Kangting Bioengineering Group Co.,Ltd.,Tianjin 300380,China)

机构地区：[1]天津科技大学生物工程学院,天津300457 [2]解放军总医院京中医疗区中关村门诊部,北京100089 [3]天津市透明质酸应用研究企业重点实验室,天津市康婷生物工程集团有限公司,天津300380

出　　处：《天津科技大学学报》2022年第4期71-80,共10页Journal of Tianjin University of Science & Technology

基　　金：国家自然科学基金资助项目(81302649);天津市透明质酸应用研究企业重点实验室开放基金资助项目(天津市康婷生物工程集团有限公司,KTRDHA-Y201906)。

摘　　要：近年来,纳米药物载体在递送抗癌药物中起到不可或缺的作用,而聚合物胶束因其具有稳定性好、可增加药物溶解度、载药能力强、不良反应少和可提高药物的生物利用度等优点在递送抗癌药物中被广泛研究.目前,已有抗癌药物的聚合物胶束制剂上市使用,并且在临床前及临床试验中得到深入研究,证明了聚合物胶束在递送抗癌药物中的巨大潜力.本文对目前聚合物胶束作为抗癌药物纳米递送载体的研究进展进行综述,着重介绍常用聚合物胶束链段材料、胶束靶向递送策略及递送抗癌药物共给药胶束系统,对聚合物胶束抗癌药物制剂的临床应用现状及上市产品进行分析概括,为相关科研人员提供参考.In recent years,nano-drug-carriers have been playing an indispensable role in the delivery of anticancer drugs.Among them,polymer micelles have received extensive attention from researchers because not only they have the advantages of good stability,good drug solubility,large drug loading and less adverse reactions,but they can also significantly improve the bioavailability of drugs.At present,polymer micelles have been commercially used for anticancer drugs,and have been thoroughly studied in preclinical and clinical trials,thus proving the great potential of polymeric micelles in the delivery of anticancer drugs.Therefore,in this article we review the current research progress of polymer micelles as nanodrug-carriers for anticancer drugs,focusing on common polymer micellar chain materials,micellar targeted delivery strategies and co-delivery micellar systems for anticancer drugs.We also summarize and analyze the clinical application status and marketing products of polymer micellar anticancer drugs.This review article is intended to provide reference for relevant researchers.

关 键 词：聚合物胶束 抗癌 靶向递送 联合用药 临床应用 

分 类 号：R915[医药卫生—微生物与生化药学]