通脉消斑膏治疗痰瘀互结型颈动脉斑块的临床研究  

Study on the Clinical Research of Tongmai Xiaoban Ointment in the Treatment of Carotid Plaque with Phlegm and Blood Stasis

作　　者：魏佳[1] 谢林林 林松俊[1] 王建军[1] 虢周科[1] WEI Jia;XIE Lin-lin;LIN Song-jun;WANG Jian-jun;GUO Zhou-ke(Shenzhen Hospital of Traditional Chinese Medicine,Guangdong Shenzhen 518000)

机构地区：[1]深圳市中医院,广东深圳518000

出　　处：《深圳中西医结合杂志》2022年第12期1-4,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广东省中医药局科研基金项目(20211327);深圳市医疗卫生三名工程项目(NO.SZZYSM202111011);深圳市科技计划项目(JCYJ20190812163201666)。

摘　　要：目的:探讨通脉消斑膏对痰瘀互结型颈动脉斑块的临床治疗效果。方法:选取深圳市中医院2021年1月至2021年12月期间收治的60例痰瘀互结型颈动脉粥样硬化患者,随机分成对照组与观察组,各30例。对照组患者给予口服辛伐他汀片治疗,观察组患者在对照组基础上联合外用通脉消斑膏。观察并比较两组患者治疗12周后的疗效、血脂水平[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、斑块指标[颈动脉内膜中层厚度(IMT)、斑块数量、斑块面积]的变化。结果:治疗12周后观察组患者的IMT低于对照组,斑块数量少于对照组,差异具有统计学意义(P<0.05);治疗12周后观察组患者的Crouse积分低于对照组,差异具有统计学意义(P<0.05);治疗12周后观察组患者的TC、TG、LDL-C低于对照组,HDL-C高于对照组,差异具有统计学意义(P<0.05);观察组患者治疗总有效率为83.33%,高于对照组的67.67%,差异具有统计学意义(P<0.05)。结论:通脉消斑膏联合口服辛伐他汀片治疗颈动脉粥样硬化能明显减轻患者症状,调控血脂水平,有助于稳定粥样斑块,可提高临床疗效。Objective To investigate the clinical effect of Tongmai Xiaoban ointment in the treatment of carotid artery plaque with phlegm and blood stasis.Methods A total of 60 patients with carotid atherosclerosis with phlegm and blood stasis treated in Shenzhen Hospital of Traditional Chinese Medicine from January 2021 to December 2021 were randomly divided into a control group and an observation group,with 30 cases in each group.The control group was treated with simvastatin tablets orally,and the observation group was treated with Tongmai Xiaoban ointment on the basis of the control group.The efficacy,blood lipid levels[triacylglycerol(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)]and the changes of plaque indexes[intima-media thickness(IMT),plaque number and plaque area]were observed and compared between the two groups after 12 weeks of treatment.Results After 12 weeks of treatment,IMT and plaque quantity in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After 12 weeks of treatment,the Crouse score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).After 12 weeks of treatment,the levels of TC,TG and LDL-C in the observation group were lower than those of the control group,while the levels of HDL-C was higher than that of the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was 83.33%,higher than 67.67%of the control group,the difference was statistically significant(P<0.05).Conclusion Tongmai Xiaoban ointment combined with oral simvastatin tablets in the treatment of carotid atherosclerosis can significantly reduce the symptoms of patients,regulate the level of blood lipid,contribute to the stabilization of atherosclerotic plaque,and improve the clinical efficacy.

关 键 词：颈动脉粥样硬化 痰瘀互结证 通脉消斑膏 辛伐他汀片 

分 类 号：R54[医药卫生—心血管疾病]