甲氧氯普胺联合格拉司琼治疗急性酒精中毒所致呕吐疗效  

Efficacy of Metoclopramide Combined with Granisetron in the Treatment of Acute Alcohol Toxicity Induced Vomiting

作　　者：黄柏芳[1] 郭建斌[1] 林俊敏[1] HUANG Bo-fang;GUO Jian-bin;LIN Jun-min(The Affiliated Hospital of Putian University,Fujian Putian 351100)

机构地区：[1]莆田学院附属医院,福建莆田351100

出　　处：《深圳中西医结合杂志》2022年第11期114-117,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:分析甲氧氯普胺联合格拉司琼治疗急性酒精中毒所致呕吐患者的临床疗效。方法:选取莆田学院附属医院2020年1月至2021年1月期间收治的70例急性酒精中毒所致呕吐患者,随机分为对照组与观察组,各35例。对照组患者给予甲氧氯普胺治疗,观察组患者给予甲氧氯普胺联合格拉司琼治疗。比较两组患者的止吐疗效、血清酒精浓度、收缩压、心率(HR)、呼吸频率(RR)、简易智力状态检查量表(MMSE)评分、血清5-羟色胺(5-HT)、β-内啡肽(β-EP)、多巴胺(DA)、去甲肾上腺素(NE)、一氧化氮(NO)、精氨酸加压素(AVP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)水平。结果:观察组患者总有效率为94.29%,高于对照组的65.71%,差异具有统计学意义(P<0.05)。治疗后两组患者的血清酒精浓度均有不同程度降低,收缩压、HR、RR均有不同程度升高,且治疗后观察组患者的血清酒精浓度低于对照组,收缩压、HR、RR高于对照组,差异具有统计学意义(P<0.05)。治疗后两组患者的5-HT、NE、DA、NO、AVP、β-EP水平均有不同程度降低,且治疗后观察组患者的5-HT、NE、DA、NO、AVP、β-EP水平低于对照组,差异具有统计学意义(P<0.05)。治疗后两组患者的AST、ALT、GGT水平均有不同程度降低,且治疗后观察组的AST、ALT、GGT水平低于对照组,差异具有统计学意义(P<0.05)。治疗后两组患者的MMSE评分均有不同程度提高,且治疗后观察组患者的MMSE评分高于对照组,差异具有统计学意义(P<0.05)。结论:甲氧氯普胺联合格拉司琼治疗急性酒精中毒所致呕吐患者疗效较好,可降低酒精浓度、降低神经递质水平。Objective To analyze the clinical effect of metoclopramide combined with granisetron in the treatment of acute alcohol toxicity induced vomiting.Methods 70 patients with acute alcohol poisoning induced vomiting admitted to the Affiliated Hospital of Putian University from January 2020 to January 2021 were randomly divided into a control group and an observation group,with 35 cases in each group.The control group was treated with metoclopramide,the observation group was treated with metoclopramide combined with granisetron.The anti-nausea efficacy,serum concentration of alcohol,systolic blood pressure,heart rate(HR),respiratory rate(RR)scale,mini-mental state examination(MMSE)score,the levels of serum 5-hydroxytryptamine(5-HT),β-endorphins(β-EP),dopamine(DA),norepinephrine(NE),nitric oxide(NO)and arginine vasopressin(AVP),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and gamma-glutamyl transpeptidase(GGT)of patients were compared between the two groups.Results The total effective rate of the observation group was 94.29%,higher than 65.71% of the control group,and the difference was statistically significant(P<0.05).After treatment,serum alcohol concentration in the two groups decreased to varying degrees,while systolic blood pressure,HR and RR increased to varying degrees.After treatment,serum alcohol concentration in the observation group was lower than that of the control group,while systolic blood pressure,HR and RR were higher than control group,the differences were statistically significant(P<0.05).After treatment,the levels of 5-HT,NE,DA,NO,AVP and β-EP in the two groups were decreased to varying degrees,and the levels of 5-HT,NE,DA,NO,AVP and β-EP in the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of AST,ALT and GGT in the two groups were decreased to varying degrees,and the levels of AST,ALT and GGT in the observation group were lower than those of the control group after treatment,the diff

关 键 词：急性酒精中毒 甲氧氯普胺 格拉司琼 

分 类 号：R595[医药卫生—内科学]