经支气管镜局部灌注两性霉素B联合氩气刀治疗肺根霉病1例  

A case report:treatment of pulmonary Rhizopus infection by bronchoscopic local infusion of amphotericin B combined with argon knife

作　　者：杨志朋 刘纯[1] 刘彩虹 刘建明[1] 谢丽华[1] YANG Zhipeng;LIU Chun;LIU Caihong;LIU Jianming;XIE Lihua(Department of Pulmonary and Critical Care Medicine,The Third Xiangya Hospital of Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅三医院呼吸与危重症医学科,长沙410013

出　　处：《中国真菌学杂志》2022年第4期300-303,共4页Chinese Journal of Mycology

摘　　要：报道1例经支气管镜局部灌注两性霉素B联合氩气刀技术治疗造血干细胞移植术后肺部小孢根霉感染。患者,男,13岁,诊断为肝炎相关性重症再生障碍性贫血,行外周血干细胞移植后出现高热、咳嗽、咳痰、气促,影像学表现为双肺感染性病变、部分实变,伴双侧胸腔积液,双下肺部分膨胀不全。经病理及二代基因测序证实为小孢根霉感染,通过支气管镜于右主支气管、右下基底段精准灌注两性霉素B治疗共16次,成功治愈。This paper reports a case of pulmonary Rhizopus microsporus infection after haematopoietic stem cell transplantation treated by transbronchoscopic local instillation of amphotericin B combined with argon knife technique.The patient was diagnosed with hepatitis-associated severe aplastic anaemia and presented with high fever,cough,sputum and shortness of breath after peripheral blood stem cell transplantation.Imaging showed infectious lesions and partial solidity in both lungs with bilateral pleural effusion and partial swelling of both lower lungs.The pathology and second-generation gene sequencing confirmed the infection as Rhizopus microsporus,which was successfully cured by bronchoscopic treatment with a total of 16 precise instillations of amphotericin B in the right main bronchus and right lower basal segment.

关 键 词：根霉 支气管镜 氩气刀 两性霉素B 

分 类 号：R519.8[医药卫生—内科学]