血清TLR4、ET-1水平与重症呼吸衰竭通气患者预后的相关性  

Correlation between serum TLR4 and ET-1 levels and the prognosis of ventilated patients with severe respiratory failure

作　　者：黄慧姣 欧阳艳[1] 黄飞鸿[1] 徐自强[1] Huang Huijiao;Ou Yang Yan;Huang Feihong;Xu Ziqiang(Department of Emergency,Chenzhou First People’s Hospital,Chenzhou,Hunan 423000,China)

机构地区：[1]郴州市第一人民医院急诊科,湖南郴州423000

出　　处：《现代科学仪器》2022年第4期108-112,共5页Modern Scientific Instruments

摘　　要：目的:分析血清Toll样受体4(TLR4)、内皮素-1(ET-1)与重症呼吸衰竭(RF)通气患者预后的关系。方法:纳入医院2018年2月-2020年2月收治84例重症RF通气患者,分为预后不良组和预后良好组;分析血清TLR4、ET-1与患者预后的关系并检验二者对患者预后不良的预测效能。结果:84例重症RF通气患者,52例预后良好,32例预后不良;经Logistic回归分析显示,血清TLR4、ET-1过表达与重症RF通气患者预后不良有关(P<0.05)。绘制ROC曲线,血清TLR4、ET-1单独及联合预测重症RF通气患者预后不良的AUC均>0.80。结论:血清TLR4、ET-1水平与重症RF通气患者预后有关,二者过表达可增加重症RF通气患者预后不良风险。Objective:To analyze the relationship between serum toll like receptor 4(TLR4),endothelin-1(ET-1)and the prognosis of ventilated patients with severe respiratory failure(RF).Methods:84 patients with severe RF ventilation treated in the hospital from February 2018 to February 2020 were included and divided into poor prognosis group and good prognosis group;the relationship between serum TLR4 and ET-1 and prognosis was analyzed,and their predictive efficacy for poor prognosis was tested.Results:Of the 84 patients with severe RF ventilation,52 had a good prognosis and 32 had a poor prognosis;Logistic regression analysis showed that the overexpression of serum TLR4 and ET-1 was related to the poor prognosis of ventilated patients with severe RF(P<0.05).The ROC curve was drawn.The AUC of serum TLR4 and ET-1 alone and combined to predict the poor prognosis of ventilated patients with severe RF were>0.80.Conclusion:The levels of serum TLR4 and ET-1 are related to the prognosis of ventilated patients with severe RF.Their overexpression can increase the risk of poor prognosis in ventilated patients with severe RF.

关 键 词：重症呼吸衰竭 血清Toll样受体4 内皮素-1 预后 相关性 

分 类 号：R563.8[医药卫生—呼吸系统]