烟曲霉特异性IgG在变应性支气管肺曲霉病诊断中的价值  

Significance of aspergillus fumigatus‑specific IgG in the diagnosis of allergic bronchopulmonary aspergillosis

作　　者：常春[1] 周剑锁[2] 刘可欣 陈爱 孙永昌[1] Chang Chun;Zhou Jiansuo;Liu Kexin;Chen Ai;Sun Yongchang(Department of Respiratory and Critical Care Medicine,Peking University Third Hospital,Beijing 100191,China;Laboratory Department,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院呼吸与危重症医学科,北京100191 [2]北京大学第三医院检验科,北京100191

出　　处：《中华医学杂志》2022年第28期2214-2216,共3页National Medical Journal of China

摘　　要：回顾性分析了北京大学第三医院2015—2021年接受烟曲霉特异性IgG检测的18例变应性支气管肺曲霉菌病(ABPA)患者的资料。其中男11例,女7例,年龄18~79岁。全部病例均有哮喘病史或咳喘症状,烟曲霉特异性IgE均阳性;血清总IgE>500 U/ml者16例,其中血清总IgE>1000 U/ml者13例。在其他诊断指标中,外周血嗜酸性粒细胞>0.5×10^(9)/L者16例;肺部CT显示有支气管扩张者15例;血清烟曲霉特异性IgG阳性(>120 AU/ml)者10例。烟曲霉特异性IgG阳性与阴性病例比较,血清总IgE水平、外周血嗜酸性粒细胞计数、支气管扩张占比差异均无统计学意义(均P>0.05)。本研究发现,ABPA患者烟曲霉特异性IgG阳性率>50%,对ABPA的诊断具有辅助价值。The data of 18 patients with allergic bronchopulmonary aspergillosis(ABPA)who received aspergillus fumigatus‑specific IgG detection from 2015 to 2021 in Peking University Third Hospital were retrospectively analyzed.Among them,11 were male and 7 were female,aged 18‑79 years.All patients had a history of asthma or symptoms of cough and asthma,and aspergillus fumigatus‑specific IgE was positive;16 patients had total serum IgE>500 U/ml,of which 13 patients had total serum IgE>1000 U/ml.Among other diagnostic indicators,peripheral blood eosinophils were>0.5×10^(9)/L in 16 cases;lung CT showed bronchiectasis in 15 cases;serum aspergillus fumigatus‑specific IgG was positive(>120 AU/ml)in 10 cases.There was no significant difference in serum total IgE level,peripheral blood eosinophil count,and bronchiectasis ratio between positive and negative cases of aspergillus fumigatus‑specific IgG(all P>0.05).In this study,the positive rate of aspergillus fumigatus‑specific IgG in patients with ABPA was more than 50%,which has auxiliary value in the diagnosis of ABPA.

关 键 词：曲霉菌病 变应性支气管肺 哮喘 烟曲霉特异性IgG 烟曲霉特异性IgE 

分 类 号：R519[医药卫生—内科学]