A ratiometric fluorescent nanoprobe based on ZIF-8@AuNCs-Tb for visual detection of 2,6-pyridinedicarboxylic acid  

作　　者：Kang Shao Siyu Wen Mengyuan Zhang Jing Wang Shiyi Ye Zaifa Pan 

机构地区：[1]College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,China [2]Institute of Animal Husbandry and Veterinary Science,Zhejiang Academy of Agricultural Sciences,Hangzhou 310002,China [3]College of Life Science,Yangtze University,Jingzhou 434023,China

出　　处：《Journal of Rare Earths》2022年第8期1165-1172,共8页稀土学报（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(21804119);Natural Science Foundation of Zhejiang Province(LZ18B050002);Natural Science Foundation of Hubei Province(2018CFB388)。

摘　　要：The rapid and sensitive detection of 2,6-pyridinedicarboxylic acid(DPA),one of the main biomarkers of Bacillus anthracis,is of great significance for the screening and diagnosing of anthrax.Herein,a ratiometric fluorescent nanoprobe based on zeolite imidazolate framework-8(ZIF-8)@AuNCs-Tb was constructed by embedding both gold nanoclusters(AuNCs)and terbium ions(Tb^(3+))into ZIF-8 for highresolution visual detection of DPA.Due to the aggregation induced emission enhancement(AIE)effect,AuNCs embedded in ZIF-8 emit a strong orange fluorescence.When Tb^(3+)is coordinated with DPA added to the nanoprobe,it will emit a strong green fluorescence owing to the antenna effect.The results reveal that ZIF-8@AuNCs-Tb nanoprobe can detect DPA effectively with a good linear relationship in the range of 40-200 and 200-1000μmol/L,the limit of detection(LOD)is estimated at 1.8μmol/L(3σ/k).The proposed nanoprobe shows a remarkable selectivity for DPA and is quite easy to realize visualization based on the fluorescent color changing from orange to green,which has potential application in clinical diagnosis.The feasibility of this method was verified by standard addition recovery experiments simulating the release of DPA from spores.

关 键 词：Terbium ions Ratiometric fluorcscent nanoprobe Visual detection Gold nanoclusters Zeolite imidazolate framework-8 Rare earths 

分 类 号：R313[医药卫生—基础医学] O657.3[理学—分析化学]