母-胎界面微环境在复发性流产中的研究进展  

Research progress of maternal-fetal interface microenvironment in recurrent abortion

作　　者：冯丹[1] 石文静 严琴 孙春青 毕星宇 张秀萍 许素铭 王耀琴 武学清 Feng Dan;Shi Wenjing;Yan Qin;Sun Chunqing;Bi Xingyu;Zhang Xiuping;Xu Suming;Wang Yaoqin;Wu Xueqing(Shanxi Medical University,Taiyuan 030001,China;Center of Reproductive Medicine,Children's Hospital of Shanxi and Women Health Center of Shanxi,Taiyuan 030013,China)

机构地区：[1]山西医科大学,太原030001 [2]山西省儿童医院山西省妇幼保健院生殖医学中心,太原030013

出　　处：《中华生殖与避孕杂志》2022年第5期518-523,共6页Chinese Journal of Reproduction and Contraception

基　　金：国家重点研发计划(2018YFC1002103)。

摘　　要：复发性流产(recurrent spontaneous abortion,RSA)是育龄期女性常见不良妊娠结局,其病因复杂,至今尚不明确。其中,母-胎界面微环境在维持妊娠方面发挥着关键作用。母-胎界面微环境主要包括滋养层细胞、蜕膜基质细胞和免疫细胞,而这些细胞数量或功能异常可能会诱发母-胎界面微环境的改变,如螺旋动脉重塑障碍、蜕膜化异常等,从而导致RSA。本文围绕这三种主要细胞在RSA发生中的作用和机制进行综述。Recurrent spontaneous abortion(RSA)is a common adverse pregnancy outcome in women of childbearing age and its etiology is complex and still not clear.The maternal-fetal interface microenvironment plays a key role in maintaining pregnancy.There are trophoblast cells,decidual stromal cells and immune cells in the maternal-fetal interface microenvironment.The abnormal number or function of these cells may induce changes in the microenvironment of maternal-fetal interface,such as spiral artery remodeling disorder and abnormal decidualization,which may lead to RSA.This review discusses the role and mechanism of these three main cells in RSA.

关 键 词：复发性流产 母-胎界面 免疫细胞 滋养层细胞 蜕膜基质细胞 

分 类 号：R714.21[医药卫生—妇产科学]