CT测量冠状动脉周围脂肪炎症的机理及应用进展  

Mechanism and Application Progress of CT Measurement of Peri-Coronary Fat Inflammation

作　　者：金鑫[1] 张兴华[1] 杨立[1] JIN Xin;ZHANG Xinghua;YANG Li(Department of Radiology,First Medical Center of General Hospital of PLA,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心放射科,北京100853

出　　处：《中国医疗设备》2022年第8期3-7,11,共6页China Medical Devices

基　　金：军队保健专项科研课题基金(13BJZ51)。

摘　　要：主要介绍了利用CT技术判断冠状动脉周围脂肪组织在炎症因子的作用下表型变化的机理,脂肪细胞是在炎症因子影响下,发生细胞内脂质减少、水分增加,且其密度也相应增加,应用CT技术通过离体和在体研究,证实了冠状动脉周围脂肪CT衰减指数(Fat Attenuation Index of Peri-Coronary,Pc-FAI)可显示脂肪表型的变化,即炎症状态越严重,Pc-FAI越高。将Pc-FAI作为冠状动脉粥样硬化炎症状态的影像生物学指标相关研究显示,Pc-FAI可用于对高危斑块识别、冠心病危险分层、抗炎治疗效果评估等。This article mainly reviewed the mechanism of using CT to judge the phenotypic changes of adipose tissue around coronary artery under the affection of inflammation. Under the influence of inflammatory factors, the intracellular lipids decreased and water content increased, and fat tissue density has increased accordingly. Through in vitro and in vivo studies using CT, it has been confirmed that the fat attenuation index of peri-coronary(Pc-FAI) could show the change of fat phenotype, that was, the heavier the inflammatory state, the higher the Pc-FAI. Studies on Pc-FAI as an imaging biological indicator of inflammatory status of coronary atherosclerosis have shown that Pc-FAI can be used to identify high-risk plaque, classify coronary heart disease risk, and evaluate the effect of anti-inflammatory treatment.

关 键 词：冠状动脉 血管周围脂肪 炎症 X线计算机体层摄影术 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病] R817.4[医药卫生—内科学]