乌司他丁联合切痂植皮术治疗重度烧伤患者的效果分析  

Effect analysis of ulinastatin combined with escharectomy and skin grafting for severe burn patients

作　　者：赵德君[1] ZHAO De-jun(Anshan Hospital,First Affiliated Hospital of China Medical University,Anshan 114000,China)

机构地区：[1]中国医科大学附属第一医院鞍山医院,114000

出　　处：《中国现代药物应用》2022年第14期152-154,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析乌司他丁联合切痂植皮术治疗重度烧伤患者的效果。方法172例重度烧伤患者,随机分为对照组及观察组,各86例。对照组应用切痂植皮术治疗,观察组在对照组基础上增加乌司他丁治疗。对比两组治疗前后的血清炎性因子、创面愈合时间、植皮成活率、术后并发症发生率。结果治疗后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)较治疗前降低,白细胞介素-10(IL-10)较治疗前增高,且观察组TNF-α(34.26±12.25)μg/L、IL-6(128.63±12.27)μg/L低于对照组的(56.38±9.37)、(205.25±15.24)μg/L,IL-10(89.35±3.91)μg/L高于对照组的(86.36±5.29)μg/L,差异有统计学意义(P<0.05)。观察组植皮成活率为98.84%(85/86),高于对照组的82.56%(71/86),创面愈合时间为(23.26±4.15)d,短于对照组的(30.26±4.29)d,差异有统计学意义(P<0.05)。观察组并发症发生率为3.49%,低于对照组的18.60%,差异有统计学意义(P<0.05)。结论针对于重度烧伤患者,应用乌司他丁联合切痂植皮术治疗能取得满意疗效。Objective To analyze the effect of ulinastatin combined with escharectomy and skin grafting for severe burn patients.Methods A total of 172 patients with severe burn were randomly divided into control group and observation group,with 86 cases in each group.The control group was treated with escharectomy and skin grafting,and the observation group was additionally treated with ulinastatin on the basis of the control group.The serum inflammatory factors before and after treatment,wound healing time,skin graft survival rate and postoperative complication rate were compared between the two groups.Results After treatment,the tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the two groups were lower than those before treatment in this group,and the interleukin-10(IL-10)was higher than before treatment in this group;the TNF-α(34.26±12.25)μg/L,IL-6(128.63±12.27)μg/L in the observation group were lower than(56.38±9.37),(205.25±15.24)μg/L in the control group,and the IL-10(89.35±3.91)μg/L was higher than(86.36±5.29)μg/L in the control group;all the differences were statistically significant(P<0.05).The skin grafting survival rate 98.84%(85/86)in the observation group was higher than 82.56%(71/86)in the control group,and the wound healing time(23.26±4.15)d was shorter than(30.26±4.29)d in the control group.All the differences were statistically significant(P<0.05).The complication rate in the observation group was 3.49%,which was lower than 18.60%in the control group,and the difference was statistically significant(P<0.05).Conclusion For severe burn patients,the application of ulinastatin combined with escharectomy and skin grafting can achieve satisfactory efficacy.

关 键 词：乌司他丁 切痂植皮术 重度烧伤 

分 类 号：R644[医药卫生—外科学]