氯解磷定联合血液灌流治疗重度急性有机磷农药中毒的效果观察  

Therapeutic effect of pralidoxime chloride combined with hemoperfusion on severe acute organophosphorus pesticide poisoning

作　　者：杨淑梅 毕梅 Yang Shumei;Bi Mei(Department of Emergency,Linfen Central Hospital,Linfen 041000,China;Department of Emergency,Xiangfen People’s Hospital,Xiangfen 041500,China)

机构地区：[1]临汾市中心医院急诊科,临汾041000 [2]襄汾县人民医院急诊科,襄汾041500

出　　处：《中国实用医刊》2022年第12期45-47,共3页Chinese Journal of Practical Medicine

摘　　要：目的观察氯解磷定联合血液灌流治疗重度急性有机磷农药中毒的效果。方法抽取2017年5月至2021年5月于临汾市中心医院治疗的重度急性有机磷农药中毒患者80例为研究对象,采用随机数字表法分为研究组和基础组,每组40例。基础组给予氯解磷定治疗,研究组给予氯解磷定联合血液灌流治疗。比较两组治疗前后血清肌钙蛋白I(cTnI)、天门冬氨酸氨基转移酶(AST)、淀粉酶(AMS)水平,记录两组治疗第3、5天胆碱酯酶活力恢复值、苏醒时间及住院时间,观察两组并发症发生情况。结果治疗后,研究组血清AMS、cTnI、AST水平均低于基础组(P均<0.05);治疗第3、5天,研究组胆碱酯酶活力恢复值均高于基础组(P均<0.05),研究组苏醒时间及住院时间均短于基础组(P均<0.05);研究组并发症发生率(7.50%,3/40)低于基础组(27.50%,11/40),P<0.05。结论重度急性有机磷农药中毒患者给予血液灌流联合氯解磷定,可改善患者血清AMS、cTnI、AST水平,促进患者恢复,减少并发症。Objective To observe the effect of pralidoxime chloride combined with hemoperfusion in the treatment of severe acute organophosphorus pesticide poisoning.Methods A total of 80 patients with severe acute organophosphorus pesticide poisoning treated in Linfen Central Hospital from May 2017 to May 2021 were selected as the research objects.They were divided into study group and basic group by random number table method,with 40 cases in each group.The basic group was treated with pralidoxime chloride,and the study group was treated with pralidoxime chloride combined with hemoperfusion.The serum levels of troponin I(cTnI),aspartate aminotransferase(AST)and amylase(AMS)in two groups were compared before and after treatment.The recovery value of cholinesterase activity on 3rd and 5th days of treatment,recovery time and hospital stay of the two groups were recorded,and the complications were compared between the two group.Results The serum levels of AMS,cTnI and AST in the study group were lower than those in the basic group(all P<0.05).On 3rd and 5th days of treatment,the recovery value of cholinesterase activity in the study group was higher than that in the basic group(all P<0.05),and the recovery time and hospital stay in the study group were shorter than those in the basic group(all P<0.05),the incidence of complications in the study group(7.50%,3/40)was lower than that in the basic group(27.50%,11/40),P<0.05.Conclusions Hemoperfusion combined with pralidoxime chloride in patients with severe acute organophosphorus pesticide poisoning can improve the levels of AMS,cTnI and AST,be conductive to recovery of patients,and reduce complications.

关 键 词：氯解磷定 血液灌流 重度急性有机磷农药中毒 

分 类 号：R595.4[医药卫生—内科学]