替格瑞洛与氯吡格雷在ST段抬高型心肌梗死患者PCI术后的应用效果比较  

Comparison on effects of ticagrelor versus clopidogrel on patients with ST-elevation myocardial infarction after PCI

作　　者：王志建 薛海英[2] 郝修宏[1] Wang Zhijian;Xue Haiying;Hao Xiuhong(Department of Cardiology II,Shangqiu First People’s Hospital,Shangqiu 476000,China;Department of Ultrasonography,Shangqiu First People’s Hospital,Shangqiu 476000,China)

机构地区：[1]商丘市第一人民医院心内2科,商丘476000 [2]商丘市第一人民医院超声科,商丘476000

出　　处：《中国实用医刊》2022年第11期98-101,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析替格瑞洛、氯吡格雷在ST段抬高型心肌梗死患者经皮冠状动脉介入术(PCI)术后的应用效果。方法抽取2018年10月至2020年9月于商丘市第一人民医院行PCI治疗的ST段抬高型心肌梗死患者86例, 按随机数字表法分为A组与B组, 每组43例。A组采用替格瑞洛联合阿司匹林治疗, B组采用氯吡格雷联合阿司匹林治疗。比较两组心功能水平[左室射血分数(LVEF)、左心室舒张末容积(LVEDV)]、炎性因子水平[C反应蛋白(CRP)、白细胞介素-6(IL-6)]、心肌损伤标志物水平[肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)]、ST段回落程度及不良反应发生率。结果治疗后, A组LVEF水平高于B组, LVEDV水平低于B组(P<0.05)。治疗后, A组血清CRP、IL-6、cTnI、CK-MB水平低于B组(P<0.05)。A组ST段回落程度优于B组(P<0.05)。A组总不良反应发生率(9.30%, 4/43)与B组(16.28%, 7/43)比较差异未见统计学意义(P>0.05)。结论相较于氯吡格雷, 替格瑞洛应用于ST段抬高型心肌梗死患者PCI术后, 更利于改善心功能, 可缓解炎症, 避免心肌损伤, ST段回落程度更优, 安全性高。Objective To analyze the effect of ticagrelor and clopidogrel on patients with ST-elevation myocardial infarction after percutaneous coronary intervention(PCI).Methods A total of 86 patients with ST-elevation myocardial infarction who underwent PCI in Shangqiu First People’s Hospital from October 2018 to September 2020 were selected,and they were divided into group A and group B by random number table method,with 43 cases in each group.The group A was treated with ticagrelor combined with aspirin,while the group B was treated with clopidogrel combined with aspirin.The levels of cardiac function assessed by left ventricular ejection fraction(LVEF)and left ventricular end-diastolic volume(LVEDV),inflammatory factors including C-reactive protein(CRP)and interleukin-6(IL-6),myocardial injury markers including cardiac troponin I(cTnI)and creatinine kinase MB isoenzyme(CK-MB),ST-segment resolution,and incidence of adverse reactions were compared between the two groups.Results After treatment,LVEF level in the group A was higher than that in the group B,and LVEDV level was lower than that in the group B(P<0.05).After treatment,serum levels of CRP,IL-6,cTnI and CK-MB in the group A were lower than those in the group B(P<0.05).ST-segment resolution in the group A was significantly better than that in the group B(P<0.05).There was no significant difference in the total incidence of adverse reactions between group A(9.30%,4/43)and group B(16.28%,7/43),P>0.05.Conclusions Compared with clopidogrel,ticagrelor applied to patients with ST-elevation myocardial infarction after PCI is more conductive to improving cardiac function,alleviating inflammation,avoiding myocardial injury,with better ST-segment resolution and high safety.

关 键 词：心肌梗死 经皮冠状动脉介入 替格瑞洛 氯吡格雷 

分 类 号：R542.22[医药卫生—心血管疾病]