中国双生子人群体重指数和冠心病遗传度和遗传相关性研究  

Heritability and genetic correlation of body mass index and coronary heart disease in Chinese adult twins

作　　者：奚玉娥 高文静[1] 洪铉明 吕筠[1] 余灿清[1] 王胜锋[1] 黄涛 孙点剑一 廖春晓[1] 庞元捷[1] 逄增昌[2] 俞敏[3] 汪华[4] 吴先萍[5] 董忠[6] 吴凡[7] 江国虹[8] 王晓节[9] 刘彧 邓健[11] 陆林[12] 曹卫华[1] 李立明[1] Xi Yu′e;Gao Wenjing;Hong Xuanming;Lyu Jun;Yu Canqing;Wang Shengfeng;Huang Tao;Sun Dianjianyi;Liao Chunxiao;Pang Yuanjie;Pang Zengchang;Yu Min;Wang Hua;Wu Xianping;Dong Zhong;Wu Fan;Jiang Guohong;Wang Xiaojie;Liu Yu;Deng Jian;Lu Lin;Cao Weihua;Li Liming(Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China;Qingdao Municipal Center for Disease Control and Prevention,Qingdao 266033,China;Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Sichuan Center for Disease Control and Prevention,Chengdu 610041,China;Beijing Center for Disease Prevention and Control,Beijing 100013,China;Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China;Tianjin Centers for Disease Control and Prevention,Tianjin 300011,China;Qinghai Center for Disease Prevention and Control,Xining 810007,China;Heilongjiang Provincial Center for Disease Control and Prevention,Harbin 150030,China;Handan Center for Disease Control and Prevention,Handan 056001,China;Yunnan Center for Disease Control and Prevention,Kunming 650034,China)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,北京100191 [2]青岛市疾病预防控制中心,青岛266033 [3]浙江省疾病预防控制中心,杭州310051 [4]江苏省疾病预防控制中心,南京210009 [5]四川省疾病预防控制中心,成都610041 [6]北京市疾病预防控制中心,北京100013 [7]上海市疾病预防控制中心,上海200336 [8]天津市疾病预防控制中心,天津300011 [9]青海省疾病预防控制中心,西宁810007 [10]黑龙江省疾病预防控制中心,哈尔滨150030 [11]邯郸市疾病预防控制中心,邯郸056001 [12]云南省疾病预防控制中心,昆明650034

出　　处：《中华预防医学杂志》2022年第7期940-946,共7页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(81973126,81711530051);公益性行业科研专项(201502006,201002007)。

摘　　要：目的评估体重指数(BMI)和冠心病的遗传度,并通过估算遗传相关性来探索二者相关的潜在机制。方法以2010—2018年中国双生子登记系统在全国11个省/直辖市调查的双生子为研究对象,通过问卷调查收集研究对象的相关信息。采用双变量结构方程模型分析BMI与冠心病的遗传度,并估算其遗传相关性。结果本研究共纳入20340对年龄≥25岁的同性别双生子。调整年龄和性别后,在双变量模型中发现BMI与冠心病患病的遗传度分别为0.52(95%CI:0.49~0.55)和0.76(95%CI:0.69~0.81),而且二者具有遗传相关性,遗传相关系数rA=0.10(95%CI:0.02~0.17)。结论在中国成年双生子人群中,BMI与冠心病患病均受遗传因素的影响,且二者的相关性可归因于具有共同的遗传基础。Objective To examine the heritability of body mass index(BMI)and coronary heart disease(CHD),and to explore whether genetic factors can explain their correlation.Methods Participants were from 11 provinces/municipalities reqistered in the Chinese National Twin Registry(CNTR)from 2010 to 2018.Participants data were collected from face-to-face questionnaire survey.Bivariate structure equation model was used to estimate the heritability and the genetic correlation of BMI and CHD.Results A total of 20340 pairs of same-sex twins aged≥25 years were included in this study.After adjusting for age and gender,the heritability of BMI and CHD was 0.52(95%CI:0.49-0.55)and 0.76(95%CI:0.69-0.81),respectively.Further,a genetic correlation was identified between BMI and CHD(rA=0.10,95%CI:0.02-0.17).Conclusion In Chinese adult twin population,BMI and CHD are affected by genetic factors,and their correlation can be attributed to the common genetic basis.

关 键 词：冠心病 体重指数 遗传度 遗传相关性 双生子研究 

分 类 号：R541.4[医药卫生—心血管疾病]