破伤风免疫制剂用于成人暴露后免疫的研究进展  

The progress on post-exposure prophylaxis of tetanus immunological preparation in adults

作　　者：杜娟 张仲松 连昕瑶 王学增 谢明珠 赵天朔 卢庆彬[1] 吴疆[2,3] Du Juan;Zhang Zhongsong;Lian Xinyao;Wang Xuezeng;Xie Mingzhu;Zhao Tianshuo;Lu Qingbin;Wu Jiang(Department of Laboratorial Science and Technology&Vaccine Research Center,School of Public Health,Peking University,Beijing 100191,P.R.China;Institute for Immunizations and Vaccines,Beijing Center for Disease Control and Prevention,Beijing 100050,China;Beijing Research Center for Preventive Medicine,Beijing 100050,China)

机构地区：[1]北京大学公共卫生学院卫生检验学系疫苗评价中心,北京100191 [2]北京市疾病预防控制中心免疫预防所,北京100050 [3]北京市预防医学研究中心,北京100050

出　　处：《中华预防医学杂志》2022年第7期1004-1010,共7页Chinese Journal of Preventive Medicine

基　　金：北京市自然科学基金-海淀原始创新联合基金(L202007);北京大学引进人才计划与启动(BMU2021YJ041)。

摘　　要：我国已经成功消除了孕妇及新生儿破伤风,但目前成人含破伤风成分疫苗接种覆盖率仍较低,发生破伤风感染的危险不容忽视。为了解破伤风对人类的威胁以及现阶段破伤风免疫制剂用于成人暴露后免疫的情况,本研究对国内外破伤风的发病情况、破伤风免疫制剂的接种现状和暴露后免疫建议等进行综述和梳理,从而为破伤风免疫制剂的暴露后免疫程序和使用规范提供科学支撑。The tetanus has been eliminated in the pregnancy women and newborns in China.However,there is a gap for adult tetanus immunization,and the risk of tetanus infection cannot be ignored.In order to clearly understand the effect of the tetanus to human beings and the current use of tetanus immunological preparation for adult post-exposure prophylaxis,the incidence of the tetanus,the use status of tetanus immunological preparation and recommendations for post-exposure prophylaxis at home and abroad were reviewed and summarized,which may provide academic evidence for post-exposure prophylaxis procedures and use of tetanus immunological preparation.

关 键 词：破伤风 破伤风免疫制剂 暴露后免疫 

分 类 号：R186[医药卫生—流行病学]