Synthesis and characterization of fluorescence active G_(4)-quartet and direct evaluation of self-assembly impact on emission  

作　　者：Ying He Mengjia Liu Shun Teng Lukasz Wojtas Guangxin Gu Xiaodong Shi 

机构地区：[1]Department of Chemistry,University of South Florida,Tampa,FL 33620,United States [2]Department of Materials Science,Fudan University,Shanghai 200438,China

出　　处：《Chinese Chemical Letters》2022年第9期4203-4207,共5页中国化学快报（英文版）

基　　金：the National Natural Science Founda-tion(No.CHE-1665122);the National Institutes of Health(No.1R01GM 120240-01)for financial support.

摘　　要：Fluorescence(FL)active 8-aryl guanosine derivatives were prepared and applied for cation mediated self-assembly to form the H-bonded G_(8)-quadruplexes.The p-cyano(p-CN)and 8-anthracene(8-An)substituted guanosines were identified to give the strongest fluorescence with the formation of G_(8)-octamers(G_(8))both in solution(NMR)and solid state(X-ray).This well-defined G_(8)-octamer system has provided the first direct evidence on the self-assembled G-quadruplex fluorescence emission with aggregation-induced emission(AIE),which could be applied as the foundation for FL molecular probe design toward G-quadruplex recognition.

关 键 词：SELF-ASSEMBLY H-BONDING G_(4)-quartet FLUORESCENCE Aggregation induced emission 

分 类 号：Q503[生物学—生物化学] O657.3[理学—分析化学]