Chlospicenes A and B,cyclopropane cracked lindenane sesquiterpenoid dimers with anti-nonalcoholic steatohepatitis activity from Chloranthus henryi  

作　　者：Jixin Li Zhirong Cui Yongyi Li Chunhua Han Yanqiu Zhang Pengfei Tang Letian Cui Hao Zhang Jun Luo Lingyi Kong 

机构地区：[1]Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China [2]School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China

出　　处：《Chinese Chemical Letters》2022年第9期4257-4260,共4页中国化学快报（英文版）

基　　金：supports from the National Natural Science Foundation of China(No.32070389);the“Double First-Class”University Project(No.CPU2018GY08)。

摘　　要：Guided by MS/MS molecular networks strategy,chlospicenes A and B(1 and 2),the first example of cyclopropane moiety cracked lindenane sesquiterpene Michael addition dimers,along with their biogenetic analogues(3 and 4),were targetedly discovered from the roots of Chloranthus henryi.Their structures including absolute configurations were characterized by NMR,ECD and X-ray diffraction analysis.The plausible biogenic pathway speculation indicated that cyclopropylcarbinyl rearrangement may dominate the key crack of cyclopropane moiety.In addition,compounds 1 and 2 showed significant anti-nonalcoholic steatohepatitis(NASH)activity in free fatty acid(FFA)-induced HepG2 cells by decreasing intracellular lipid accumulation.

关 键 词：Chloranthus henryi. Lindenane sesquiterpenoid dimer Molecular networks Cyclopropylcarbinyl rearrangement Anti-nonalcoholic steatohepatitis 

分 类 号：O629[理学—有机化学]