Octacyclic and decacyclic ent‑abietane dimers with cytotoxic activity from Euphorbia fischeriana steud.  

作　　者：Yulin Peng Yibo Chang Chengpeng Sun Weiyi Wang Chao Wang Yan Tian Baojing Zhang Sa Deng Wenyu Zhao Xiaochi Ma 

机构地区：[1]College of Pharmacy,College of Integrative Medicine,Dalian Medical University,Dalian 116044,China [2]Second Affiliated Hospital,Dalian Medical University,Dalian 116023,China [3]Key Laboratory of Marine Biogenetic Resources,Third Institute of Oceanography,Ministry of Natural Resources,Xiamen 361005,China

出　　处：《Chinese Chemical Letters》2022年第9期4261-4263,共3页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.81930112);Distinguished Professor Program of Liaoning Province(No.XLYC2002008);Natural Science Foundation of Liaoning Province(Nos.2020-BS-203 and 2020-MS-256);Natural Science Foundation of Fujian Province(No.2021J01509).

摘　　要：A novel Diels-Alder adduct possesses a 6/6/6/5/6/6/6/6 octacyclic skeleton featured with bicyclo[2.2.2]octane moiety,biseupyiheoid A(1),along with another decacyclic 6/6/6/3/5/6/5/6/6/6 fused diterpenoid dimer,bisfischoid C(2),were isolated from Euphorbia fischeriana.Their structures were determined by spectroscopic,X-ray crystallographic approaches,and quantum mechanical calculations.The structural features of 1 and 2 were hypothesized to involve intramolecular Diels-Alder reactions with different coupling patterns.Dimer 1 showed antiproliferative activity through apoptosis activation in LoVo cells.

关 键 词：Ditrpenoid dimers Euphorbia fischerianaent-Abietanes Diels-Alder adduct Cytotoxic effect 

分 类 号：O629.61[理学—有机化学]