Forrestiacids C and D,unprecedented triterpene-diterpene adducts from Pseudotsuga forrestii  

作　　者：Peng-Jun Zhou Yi Zang Cong Li Lin Yuan Huaqiang Zeng Jia Li Jin-Feng Hu Juan Xiong 

机构地区：[1]Department of Natural Medicine,School of Pharmacy,Fudan University,Shanghai 201203,China [2]School of Pharmaceutical Sciences,Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation,Taizhou University,Taizhou 318000,China [3]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [4]College of Chemistry and Bioengineering,Hunan University of Science and Engineering,Yongzhou 425199,China [5]Frontier Research Center for Multidisciplinary Sciences,School of Chemistry and Chemical Engineering,Northwestern Polytechnical University,Xi'an 710072,China

出　　处：《Chinese Chemical Letters》2022年第9期4264-4268,共5页中国化学快报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.21937002,81773599,21772025)。

摘　　要：Forrestiacids C(1)and D(2),a pair of C-25 epimeric triterpene–diterpene adducts were isolated from the needles and twigs of the vulnerable conifer Pseudotsuga forrestii.This unprecedented class of compounds might be generated via an intermolecular Michael addition reaction of a rearranged 6/6/5/5-fused spiro-lanostene with an abietene.Their structures were established by spectroscopic data and X-ray crystallography.The adducts showed inhibitory activities against the ATP-citrate lyase(ACL)and acetyl-CoA carboxylase 1(ACC1),two rate-limiting enzymes in the de novo lipogenesis pathway.

关 键 词：Forrestiacid Pseudotsuga forrestii PINACEAE Michael adduct Lipogenesis inhibitor 

分 类 号：O629.61[理学—有机化学]