A tandem asymmetric oxidation-oxa-Michael sequence for dearomatization ofβ-naphthols  

作　　者：Linqing Wang Haiyong Zhu Tianyu Peng Yingfan Xu Yanzhe Hou Shixin Li Shiming Pang Hailong Zhang Dongxu Yang 

机构地区：[1]Key Laboratory of Preclinical Study for New Drugs of Gansu Province,Institute of Drug Design&Synthesis,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China

出　　处：《Chinese Chemical Letters》2022年第9期4273-4276,共4页中国化学快报（英文版）

基　　金：the financial support from the National Natural Science Foundation of China (Nos. 21901092, 21807053);Innovation Fund for Medical Sciences (No. 2019-12M-5-074);Program for Chang-jiang Scholars and Innovative Research Team in University (PCSIRT) (No. IRT_15R27);the Funds for Fundamental Research Creative Groups of Gansu Province (No. 20JR5RA310);the Fundamental Research Funds for the Central Universities (Nos. lzujbky2020-49, 2021-kb21)

摘　　要：A catalytic asymmetric hydroxylative dearomatization reaction has been disclosed,and the products can smoothly transform into spiroannulation adducts by simply treated with a base under mild conditions.Novel in-situ generated magnesium catalytic methods are developed by application of combinational ligands.Related concise transformaitons of the spiroannulation adducts have been carried out.

关 键 词：Oxidative dearomatization Oxa-Michael reaction Asymmetric reaction Chiral ligands Magnesium catalyst 

分 类 号：O621.251[理学—有机化学]