左西替利嗪较西替利嗪治疗变应性鼻炎或荨麻疹有效性和安全性的系统评价  

Comparative efficacy and safety of Levocetirizine and Cetirizine in the treatment of allergic rhinitis and urticaria:a systematic evaluation

作　　者：郑子恢[1,2] 金鹏飞[1,2] 张亚同[1,2] 李可欣[3] 赵紫楠[1,2] 潘慧杰[4] 胡欣[1,2] ZHENG Zi-hui;JIN Peng-fei;ZHANG Ya-tong;LI Ke-xin;ZHAO Zi-nan;PAN Hui-jie;HU Xin(Department of Pharmaceutical,Chinese Academy of Medical Sciences,Beijing 100730,China;Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application,Chinese Academy of Medical Sciences,Beijing 100730,China;Beijing Hospital Clinical Trial Center,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Laboratory,Beijing Hospital,Clinical Laboratory National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]北京医院药学部,北京100730 [2]北京医院北京市药物临床风险与个体化应用评价重点实验室,北京100730 [3]北京医院临床试验研究中心,北京100730 [4]北京医院检验科国家老年医学中心中国医学科学院老年医学研究院,北京100730

出　　处：《临床药物治疗杂志》2022年第7期23-31,共9页Clinical Medication Journal

基　　金：国家重点研发计划(2020YFC2009001);国家卫健委药政司委托课题(NHC-YZS-202103)。

摘　　要：目的系统评价左西替利嗪对比西替利嗪治疗变应性鼻炎或荨麻疹的有效性和安全性。方法计算机检索Cochrane Library、PubMed、Embase、CNKI、WangFang Data和CBM数据库等中英文数据库,收集从建库到2022年5月中国科技论文核心期刊发表的评价左西替利嗪较西替利嗪治疗变应性鼻炎和荨麻疹的随机对照试验(RCT),英文数据库不做期刊限制。2名研究者独立审查文献,收集数据,并评估纳入研究的潜在偏倚。结果共纳入9项RCT结果,共计935例患者,左西替利嗪为观察组,共468例,西替利嗪为对照组,共467例。Meta分析结果显示:有效性方面,观察组在第1周至第4周总有效率方面虽略优于对照组,但差异无统计学意义:第1周(OR=1.08,95%CI:0.66~1.75,P>0.05),第2周(OR=1.44,95%CI:0.91~2.29,P>0.05),第4周(OR=1.40,95%CI:0.84~2.33,P>0.05);不良反应方面,观察组明显低于对照组(OR=0.55,95%CI:0.35~0.86,P<0.01),差异具有统计学意义,其中嗜睡发生率方面,观察组明显低于对照组(OR=0.46,95%CI:0.26~0.80,P<0.01),差异有统计学意义。结论左西替利嗪与西替利嗪在有效性方面基本一致,安全性方面左西替利嗪较西替利嗪嗜睡发生率更低。Objective To systematically evaluate the efficacy and safety of Levcetirizine versus Cetirizine in the allergic rhinitis and urticaria.Methods The Cochrane Library,PubMed,Embase,CNKI,WangFang and CBM databases were computer searched.The randomized controlled trials(RCTs)on evaluation of Levocetirizine and Cetirizine in the treatment of allergic rhinitis and urticaria were collected in The key magazine of China technology from the date of datebases establishment to May2022,while there was on journal restrictions with the English databases.Two investigators independently reviewed the literature,collected data,and assessed potential bias for inclusion.Result A total of 9 RCTS were included,including 935 patients,Levocetirizine was the study group with 468 cases and Cetirizine was the Control group with 467 cases.Meta-analysis showed that the total effective rate of the observation group from the first week to the fourth week was slightly better than that of the control group,but the difference was not statistically significant:week 1(OR=1.08,95%CI:0.66-1.75,P>0.05),week 2(OR=1.44,95%CI:0.91-2.29,P>0.05),week 4(OR=1.40,95%CI:0.84-2.33,P>0.05).In terms of adverse reactions,the study group was significantly lower than the control group(OR=0.55,95%CI:0.35-0.86,P<0.01),the difference was statistically significant.In terms of the incidence of drowsiness,the study group was significantly lower than the control group(OR=0.46,95%CI:0.26-0.80),P<0.01),the difference was statistically significant.Conclusion Available evidence suggests that Levocetirizine is generally Consistent with Cetirizine in terms of efficacy,and Levocetirizine has a lower incidence of drowsiness than Cetirizine in terms of safety.

关 键 词：左西替利嗪 西替利嗪 荨麻疹 变应性鼻炎 META分析 随机对照试验 

分 类 号：R976[医药卫生—药品]