基于数据挖掘的国医大师潘敏求治疗原发性肺癌方药规律研究  

Research on the prescription rules of national master of Chinese medicine PAN Minqiu in the treatment of primary lung cancer based on data mining

作　　者：周玮玮 唐蔚[2] 潘博[1] 宋程 任迪莎 白子璇 ZHOU Weiwei;TANG Wei;PAN Bo;SONG Cheng;REN Disha;BAI Zixuan(Hunan University of Chinese Medicine,Changsha,Hunan 410208,China;Affiliated Hospital of Hunan Academy of Chinese Medicine,Changsha,Hunan 410006,China;Hunan Cancer Hospital,Changsha,Hunan 410013,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南省中医药研究院附属医院,湖南长沙410006 [3]湖南省肿瘤医院,湖南长沙410013

出　　处：《湖南中医药大学学报》2022年第8期1242-1246,共5页Journal of Hunan University of Chinese Medicine

基　　金：长沙市科技局基金项目(202039)。

摘　　要：目的挖掘国医大师潘敏求治疗原发性肺癌的用药经验,为原发性肺癌的临床治疗以及新药研发提供参考与借鉴。方法采集2016年1月至2020年12月湖南省中医药研究院附属医院潘敏求教授门诊就诊的肺癌患者病历281则,使用中医传承计算平台V3.0建立数据库,并运用中医传承计算平台V3.0中的频次统计、关联规则、聚类分析等方法,结合临床,探究潘敏求教授应用中医药治疗原发性肺癌的用药经验。结果肺癌患者以阴虚内热型、气阴两虚型证型为主,常见症状为咳嗽、失眠、痰色白等。药物的用药频次以补虚类、清热类为主;常用基础方剂为脾肾方(人参、黄芪、白术、茯苓、灵芝、枸杞子、女贞子、菟丝子);除基础方脾肾方与甘草以外的药对,主要为半枝莲-白花蛇舌草清热解毒组合,夏枯草-牡蛎散结消肿、滋阴潜阳组合,重楼-莪术消积破瘀组合。结论肺癌患者以阴虚内热型、气阴两虚型多见,潘敏求教授治疗原发性肺癌的常用治法为养阴益气、清热解毒,用药注重寒热平调,扶正驱邪并重。Ojective To explore the experience of national master of Chinese medicine PAN Minqiu in the treatment of primary lung cancer,to provide reference for the clinical treatment of primary lung cancer and the research and development of new drugs.Methods A total of 281 medical records of lung cancer patients treated by professor PAN Minqiu from January 2016 to December 2020 of the Affiliated Hospital of Hunan Academy of Chinese Medicine were collected,and the database was established using the traditional Chinese medicine inheritance computing platform V3.0.Based on the frequency statistics,association rules,cluster analysis and other methods in the traditional Chinese medicine inheritance computing platform V3.0,combined with clinical practice,this paper explores professor PAN Minqiu's experience in the application of traditional Chinese medicine in the treatment of primary lung cancer.Results The main types of lung cancer patients were Yin deficiency and internal heat type,Qi and Yin deficiency type.The common symptoms were cough,insomnia,and white phlegm.The frequency of drug use was mainly tonic and heat-clearing.The commonly used basic prescriptions were spleen and kidney prescription[Renshen(Ginseng Radix Et Rhizoma),Huangqi(Astragali Radix),Baizhu(Atractylodis Macrocephalae Rhizoma),Fuling(Poria),Lingzhi(Ganoderma),Gouqizi(Lycii Fructus),Nvzhenzi(Ligustri Lucidi Fructus),Tusizi(Cuscutae Semen)];in addition to the basic prescription spleen and kidney prescription and Gancao(Glycyrrhizae Radix Et Rhizoma),other medicine pairs were mainly the combination of Banzhilian(Scutellariae Barbatae Herba)-Baihuasheshecao(Hedyotis Diffusa)to clear heat and detoxify,the combination of Xiakucao(Prunellae Spica)-Muli(Ostreae Concha)to disperse nodules and detumescence,nourish Yin and suppress Yang,and the combination of Chonglou(Paridis Rhizoma)-Ezhu(Curcumae Rhizoma)to eliminate accumulation and break stasis.Conclusion Lung cancer patients are more common with Yin deficiency and internal heat type,Qi and Yin deficiency type.P

关 键 词：原发性肺癌 中医传承计算平台 用药规律 脾肾方 益气养阴 清热解毒 潘敏求 

分 类 号：R273[医药卫生—中西医结合]