Recent advances in the synthesis of fluoroalkylated compounds using fluoroalkyl anhydrides  

作　　者：Wei Wu Yi You Zhiqiang Weng 

机构地区：[1]Fujian Engineering Research Center of New Chinese lacquer Material,College of Materials and Chemical Engineering,Minjiang University,Fuzhou 350108,China [2]Key Laboratory of Molecule Synthesis and Function Discovery,and Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials,College of Chemistry,Fuzhou University,Fuzhou 350108,China

出　　处：《Chinese Chemical Letters》2022年第10期4517-4530,共14页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21772022,and 22171124);Minjiang University(No.MJY21041);Fuzhou University.

摘　　要：Fluoroalkyl-containing organic compounds have exhibited wide applications in the field of pharmaceuticals,agrochemicals and materials science due to their outstanding properties such as biological activity,metabolic stability,lipophilicity,excellent chemical and thermal stability.Therefore,various synthetic strategies have been developed for the construction of fluoroalkyl-containing compounds,using highly active fluorinating reagents and fluorinated building blocks.Recently,the use of easily available and inexpensive trifluoroacetic anhydride(TFAA)and its anhydride analogues has attracted great attention to access numerous fluoroalkyl-containing compounds through cyclization and coupling reactions.In this review,we summarized the recent advances in the synthesis of fluoroalkylated compounds using fluoroalkyl anhydrides as reagents.This review aims to provide a reference for researchers on how to develop new synthetic straregies of fluorine-containing organic compounds and achieve kilograms or even tons preparation of fluorine-containing organic compounds using fluoroalkyl anhydrides.

关 键 词：Trifluoroacetic anhydride(TFAA) Fluoroalkyl anhydride Fluoroalkyl-containing organic compound Fluoroalkl Fluoroalkanoyl Cyclization reaction Coupling reaction 

分 类 号：O622[理学—有机化学]