pH- and H_(2)O_(2)-sensitive drug delivery system based on sodium xanthate:Dual-responsive supramolecular vesicles from one functional group  

作　　者：Ziyan Shen Ning Ma Feng Wang Jiaming Ren Chenxi Hou Shuang Chao Yuxin Pei Zhichao Pei 

机构地区：[1]Shaanxi Key Laboratory of Natural Products&Chemical Biology,College of Chemistry&Pharmacy,Northwest A&F University,Yangling 712100,China

出　　处：《Chinese Chemical Letters》2022年第10期4563-4566,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21877088.22171230);China Postdoctoral Science Foundation(No.2016M602861).

摘　　要：Nano-drug delivery systems with multiple stimulus-responsive capabilities have superior response performance and efficient drug release.Nevertheless,it is sophisticated to construct multiple stimulus-responsive systems where the two or more functional groups need to be introduced simultaneously.Xanthate,one functional group with pH and H2O2 stimulus responsiveness,has significant potential applications for building dual-responsive drug delivery system.Herein,we present a novel dual stimuli-responsive supramolecular drug delivery system by using sodium xanthate derivative(SXD)as guest molecule and quaternary ammonium capped pillar[5]arene(QAP5)as host molecule through host-guest interaction on the basis of electrostatic interaction.The amphiphile QAP5⊃SXD could self-assemble into vesicles to efficiently load the anti-cancer drug DOX.The experimental results showed that QAP5⊃SXD nanoparticles could achieve efficient drug delivery and controlled release in the tumor microenvironment.Cytotoxicity experiments proved that DOX@QAP5⊃SXD nanoparticles could significantly improve the anticancer efficiency of free DOX on cancer cells.The present study provides an efficient strategy to develop supramolecular nanocarriers with dual-responsiveness in one functional group for controlled drug release.

关 键 词：arene Sodium xanthate Host-guest interaction pH-and H_(2)O_(2)-dual responsive Controllable drug delivery 

分 类 号：TQ460.4[化学工程—制药化工] TB383.1[一般工业技术—材料科学与工程]