A hybrid nano-assembly with synergistically promoting photothermal and catalytic radical activity for antibacterial therapy  

作　　者：Yunxia Wang Chuangxin Zhang Hui Zhang Liheng Feng Libing Liu 

机构地区：[1]School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China [2]Department of Nutrition and Health,China Agricultural University,Beijing 100193,China [3]Beijing National Laboratory for Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Chinese Chemical Letters》2022年第10期4605-4609,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21977065,22177065 and 21807067);Sanjin Scholars Support Planunder Special Funding(No.2017-06);Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(Nos.201802106,2019L0022);Supported by the Fund for Shanxi“1331”Project(1331);the Program for Introducing Overseas High-level Talents of Shanxi(Hundred Talents Plan)。

摘　　要：It is of great significance to develop effective antibacterial agents and methods to combat drug resistant bacterial infections due to its increasing threaten to human health and the ineffectiveness of antibiotics.Herein,a multifunctional hybrid nano-assembly(M1-Fe NPs)based on conjugated oligomer and ferrous ion was engineered with favorable bactericidal activity for synergetic antibacterial therapy.The chelation of ferrous ion not only enhances the photothermal conversion efficiency of M1 but also endows the nano-assembly with catalytic capability of transferring H_(2)O_(2) into stronger oxidant hydroxyl radicals(·OH).Meanwhile,the generated heat can further promote the Fenton reaction activity.By generating cytotoxic heat and oxidative·OH,M1-Fe NPs can effectively kill Staphylococcus aureus in vitro and in vivo with the aid of low dosage of H_(2)O_(2).The work provides a new multifunctional platform for combinational drug resistant antibacterial therapy and even antitumor therapy.

关 键 词：Conjugated oligomer NANO-ASSEMBLY Fenton reaction Photothermal therapy Bacterial infections 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R318[医药卫生—生物医学工程]