2018年深圳市老年人非酒精性脂肪肝患病率及相关因素  

Prevalence and factors of nonalcoholic fatty liver disease among elderly in Shenzhen City in 2018

作　　者：袁雪丽[1] 倪文庆[1] 李娉 张红敏 张艳 徐健[1] Yuan Xueli;Ni Wenqing;Li Ping;Zhang Hongmin;Zhang Yan;Xu Jian(Shenzhen Center for Chronic Diseases Control,Shenzhen 518020,China)

机构地区：[1]深圳市慢性病防治中心,深圳518020

出　　处：《卫生研究》2022年第4期585-590,共6页Journal of Hygiene Research

基　　金：深圳市卫生计生系统科研项目(No.SZGW2018002);深圳市医疗卫生三名工程(No.SZSM201811093);深圳市科技计划项目(No.JCYJ20180703145202065);深圳市医学重点学科建设经费资助。

摘　　要：目的分析深圳市老年人非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)患病率及相关因素。方法2018年1—12月采用方便抽样方法,选取深圳市社区121042名65岁及以上常住居民为调查对象,通过问卷调查、体格检查、生化检查和B超检查,采集社会人口学信息、生活方式、身高、体重、腰围、血压、空腹血糖、血脂、既往史和肝脏B超检查结果等信息。进行多因素二分类Logistic回归分析。结果研究对象中NAFLD患者33179人(27.41%)。经Logistic回归分析,调整心脑血管疾病史和体力活动状态后发现,男性(OR=0.633,95%CI 0.612~0.654)、文盲(OR=0.761,95%CI 0.720~0.804)及小学(OR=0.889,95%CI 0.862~0.916)、现在吸烟(OR=0.719,95%CI 0.675~0.767)、曾经吸烟(OR=0.802,95%CI 0.749~0.859)、偏瘦(OR=0.157,95%CI 0.128~0.193)与研究对象NAFLD患病均呈显著负相关(P<0.01),而65~79岁、肥胖(OR=4.744,95%CI 4.511~4.989)、超重(OR=2.421,95%CI 2.341~2.504)、中心型肥胖(OR=1.823,95%CI 1.764~1.883)、高血压(OR=1.101,95%CI 1.069~1.134)、糖尿病(OR=1.578,95%CI 1.528~1.630)和血脂异常(OR=1.685,95%CI 1.639~1.734)与研究对象NAFLD患病均呈显著正相关(P<0.01)。结论2018年深圳市老年人NAFLD患病率相对全国水平较低,但绝对值较高;女性、文化程度较高、超重、肥胖、中心型肥胖、患高血压、糖尿病和血脂异常的老年人NAFLD患病率较高。OBJECTIVE To analyze the prevalence and influence factors of nonalcoholic fatty liver disease(NAFLD)among elderly in Shenzhen City.METHODS From January to December in 2018,a convenient sampling method was used to select 121042 survey subjects from Shenzhen community residents aged 65 years and above through questionnaire survey,physical examination,laboratory biochemical examination and b-ultrasound examination,demographic information,lifestyle,height,weight,waist circumference,blood pressure,fasting blood glucose,blood lipids,past history and liver B ultrasound result were collected.A total of 121042 of the subjects were selected for the study with complete information.The logistic regression analysis were used to analyze the data.RESULTS There were 33179 NAFLD patients(27.41%).The variables adjusted by logistic regression analysis revealed that male(OR=0.633,95%CI 0.612-0.654),illiteracy(OR=0.761,95%CI 0.720-0.804),primary school education(OR=0.889,95%CI 0.862-0.916),current smoking(OR=0.719,95%CI 0.675-0.767),former smoking(OR=0.802,95%CI 0.749-0.859),low-weight(OR=0.157,95%CI 0.128-0.193)was negatively correlated with NAFLD(P<0.01).65-79 years old,obesity(OR=4.744,95%CI 4.511-4.989),overweight(OR=2.421,95%CI 2.341-2.504),central obesity(OR=1.823,95%CI 1.764-1.883),hypertension(OR=1.101,95%CI 1.069-1.134),diabetes(OR=1.578,95%CI 1.528-1.630)and dyslipidemia(OR=1.685,95%CI 1.639-1.734)was positive correlation with NAFLD(P<0.01).CONCLUSION The prevalence of NAFLD among the elderly in Shenzhen City is relatively low compared with the national level,but its absolute value is higher.The prevalence of NAFLD is higher among the elderly who are female,highly educated,overweight,obese,central obese,suffering from hypertension,diabetes and dyslipidemia.

关 键 词：老年人 非酒精性脂肪肝 相关因素 

分 类 号：R181.37[医药卫生—流行病学] R181.23[医药卫生—公共卫生与预防医学]