长双歧杆菌与婴幼儿肠道健康的研究进展  

Advances in Bifidobacterium longum and intestinal health during infancy

作　　者：吴诗寅 蔡美琴[1] WU Shiyin;CAI Meiqin(School of Public Health,Shanghai Jiao Tong University,Shanghai 200025,China)

机构地区：[1]上海交通大学公共卫生学院,上海200025

出　　处：《临床儿科杂志》2022年第9期715-720,共6页Journal of Clinical Pediatrics

摘　　要：长双歧杆菌是一种对肠道有益的共生菌,与婴幼儿肠道健康密切相关。文章介绍了长双歧杆菌的生理特性与基因组学、代谢组学和蛋白组学水平的生物学特性,在治疗或缓解婴幼儿胃肠道疾病方面的益生功能,及其在国内外的研究进展与应用发展前景。分析了不同菌株的长双歧杆菌治疗婴幼儿功能性便秘、肠易激综合征和炎症性肠炎的功效作用和可能机制。以期为长双歧杆菌应用于临床治疗或缓解婴幼儿胃肠道疾病提供科学依据,为长双歧杆菌功能性菌株的开发及其用于促进肠道健康的深入研究提供思路。Bifidobacterium longum is a commensal microbiota beneficial to the intestine,which i s closely related to gut health during infancy.This paper reviews the physiological characteristics and the biological characteristics of genomics,metabolomics and proteomics,the prebiotic function in treating or alleviating gastrointestinal diseases in infants,and the research progress and application development prospect at home and abroad of Bifidobacterium longum.This review also analyzes the efficacy and possible mechanism of different strains of Bifidobacterium longum in the treatment of infantile functional constipation,irritable bowel syndrome and inflammatory bowel disease in order to provide scientific basis for the application of Bifidobacterium longum in clinical treatment or alleviation of gastrointestinal diseases in infants,and provide ideas for the development of Bifidobacterium longum functional strains and their in-depth research on promoting intestinal hea lth.

关 键 词：长双歧杆菌 婴幼儿肠道健康 功能性便秘 肠易激综合征 炎症性肠炎 基因组学 

分 类 号：R725.7[医药卫生—儿科]