复方苦参注射液配伍稳定性研究  

Clinical Stability Study of Compound Kushen Injection(CKI)

作　　者：段秀梅 王鹏飞 张亚锰 毕小凤 秦文杰 海丽娜 Duan Xiumei;Wang Pengfei;Zhang Yameng;Bi Xiaofeng;Qin Wenjie;Hai Lina(Beijing Zhendong Guangming Pharmaceutical Research Institute,Beijing 100085,China)

机构地区：[1]北京振东光明药物研究院,北京100085

出　　处：《亚太传统医药》2022年第8期81-86,共6页Asia-Pacific Traditional Medicine

基　　金：国家中药标准化项目(ZYBZH-C-JIN-43);国家重点研发计划(2017YFC1701900)。

摘　　要：目的:考察复方苦参注射液与0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液配伍的稳定性。方法:复方苦参注射液分别在0.9%氯化钠注射液(250mL)、5%葡萄糖注射液(250mL)、10%葡萄糖注射液(250mL)中室温放置8h,观察其外观、p H值、不溶性微粒及甲基氧化偶氮甲醇樱草糖苷、苦参碱、槐果碱、槐定碱、氧化槐果碱、氧化苦参碱、番石榴酸、三叶豆紫檀苷的含量变化情况。结果:复方苦参注射液与0.9%氯化钠注射液、5%葡萄糖注射液和10%葡萄糖注射液配伍后8h内质量稳定。结论:复方苦参注射液可与0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液配伍。Objective:To investigate the compatibility stability of CKI with 0.9% sodium chloride injection,5% glucose injection and 10% glucose injection.Methods:The CKI was separately placed in 0.9% sodium chloride injection(250 mL),5% glucose injection(250 mL) and 10% glucose injection(250 mL) at room temperature for 8 hours,then observed the changes of its appearance,pH value,insoluble particles as well as the contents of macrozamin,matrine,sophocarpine,sophoridine,oxysophocarpine,oxymatrine,piscidic acid and trifolirhizin.Results:The qualities of CKI were stable within 8 hours after its compatibility with 0.9% sodium chloride injection,5 % glucose injection or 10 % glucose.Conclusion:CKI can be compatible with 0.9% sodium chloride injection,5 % glucose injection and 10 % glucose respectively.

关 键 词：复方苦参注射液 0.9%氯化钠注射液 5%葡萄糖注射液 10%葡萄糖注射液 配伍稳定性 

分 类 号：R286[医药卫生—中药学]