Study of a water-soluble supramolecular complex of curcumin andβ-cyclodextrin polymer with electrochemical property and potential anti-cancer activity  

作　　者：Wang Zhang Ping Xiao Liwei Lin Fang Guo Qingyue Wang Yuanzhe Piao Guowang Diao 

机构地区：[1]School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou 225002,China [2]Department of Applied Bioengineering,Graduate School of Convergence Science and Technology,Seoul National University,Suwon 443-270,Republic of Korea [3]Shanghai Suni Biotechnology Development Co.,Ltd.,Shanghai 201300,China [4]Advanced Institutes of Convergence Technology,Suwon 443-270,Republic of Korea

出　　处：《Chinese Chemical Letters》2022年第8期4043-4047,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21703200 and 21773203);the Chey Institute for Advanced Studies International Scholar Exchange Fellowship for the Academic Year of 2021-2022;China Scholarship Council Program(No.201908320084)。

摘　　要：As a member of the curcuminoid compound family,curcumin(Cur)has many interesting therapeutic properties.However,its low aqueous solubility and stability have resulted in poor bioavailability and restricted clinical efficacy.Based on size matching,β-cyclodextrin polymer(β-CDP),with its hydrophilic polymer chains and hydrophobic cavities,can form an inclusion complex with Cur.To improve the water solubility and stability of Cur,a simple and eco-friendly grinding method was designed to formβ-CDP inclusion complexes.According to the Boltzmann-Hamel's method and Job's method,the molar ratio of theβ-CD unit inβ-CDP to Cur was determined to be 1:1.The diffusion coefficient and diffusion activation energy of Cur-β-CDP were calculated in an electrochemical study.This supramolecular complex worked well in vitro to inhibit the proliferation of hepatoma carcinoma cells HepG2.Remarkably,this method visibly reduced the undesirable side effects on normal cells,without weakening the anti-cancer activity of the drugs.We expect that the obtained host-guest complex will provide a new approach for delivering natural drug molecules,having low water solubility.

关 键 词：Cyclodextrin polymer CURCUMIN SOLUBILITY Anti-cancer activity Supramolecular complex 

分 类 号：TQ460.4[化学工程—制药化工]