Lewis acid-catalyzed enantioselective Friedel-Crafts reaction of pyrazole-4,5-diones withβ-naphthol  

作　　者：Yangmian Lu Jindong Li Weizhi Gu Ning Li Zhenggen Zha Zhiyong Wang 

机构地区：[1]Hefei National Laboratory for Physical Sciences at Microscale,Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences,School of Chemistry and Materials Science,University of Science and Technology of China,Hefei 230026,China

出　　处：《Chinese Chemical Letters》2022年第8期4048-4052,共5页中国化学快报（英文版）

基　　金：the financial support from the Natural Science Foundation of China(No.21772185);National Natural Science Foundation of China(No.22001241);supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000)。

摘　　要：A series of pyrazolone derivatives bearing a tetrasubstituted chiral center were prepared by virtue of a Lewis acid-catalyzed Friedel-Crafts reaction,in which a chiral copper complex was employed as the catalyst.This reaction can be carried out smoothly under mild condition to afford the pyrazolone derivatives with high yields(up to 85%)and excellent enantioselectivities(up to 99%).In addition,the gram scale synthesis proved the practicality of this reaction.

关 键 词：Asymmetry Friedel-Crafts reaction Lewis acid-catalyst Pyrazole-4 5-diones Β-NAPHTHOL 

分 类 号：O626[理学—有机化学]