Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles for ovalbumin delivery  

作　　者：Yingying Song Chang-Ming Dong 

机构地区：[1]School of Chemistry and Chemical Engineering,Shanghai Key Laboratory of Electrical Insulation and Thermal Aging,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Chinese Chemical Letters》2022年第8期4084-4088,共5页中国化学快报（英文版）

基　　金：the financial support of the National Natural Science Foundation of China(Nos.22075176 and21774074)。

摘　　要：Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles were disclosed for ovalbumin(OVA)delivery system.The mannose-coated polypeptide nanoparticles can induce strongest targeting and immune adjuvant effects to macrophages than those glucose/lactose-coated ones,which effectively transported OVA into cells and facilitated OVA subcellular escape from endolysosomes into cytoplasm with the assistance of UV irradiation or intracellular acidic pH.

关 键 词：Polypeptide nanoparticles Sugar targeting Immune adjuvant Ovalbumin delivery system 

分 类 号：R943[医药卫生—药剂学] TB383.1[医药卫生—药学]