局部亚低温治疗急性大面积脑梗死的效果观察  

Effect observation of local mild hypothermia on acute massive cerebral infarction

作　　者：李瀛 侯丹[1] 刘炫君[1] 余丹[1] 王良 LI Ying;HOU Dan;LIU Xuan-jun;YU Dan;WANG Liang(Department of Neurology,Haikou Hospital Affiliated to Xiangya Medical College,Central South University,Haikou Hainan Province 570208,China)

机构地区：[1]中南大学湘雅医学院附属海口医院神经内科,海南海口570208

出　　处：《中国城乡企业卫生》2022年第7期171-173,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

基　　金：海南省自然科学基金项目(812166)。

摘　　要：目的探究急性大面积脑梗死患者在采取局部亚低温方法治疗的临床效果以及患者治疗前后血清血小板活化因子PAF、PF4、β-TG、CD62p水平变化情况。方法纳入2013年2月—2014年6月中南大学湘雅医学院附属海口医院神经内科收治的100例急性大面积脑梗死患者为研究对象,按随机数字表法分为常规治疗组和局部亚低温治疗组各50例。常规治疗组患者采用常规治疗,局部亚低温治疗组患者在常规治疗者基础上采用局部亚低温脑保护仪治疗。比较两组治疗前、治疗48 h、7 d时血小板活化物PAF、PF4、β-TG、CD62p的水平及美国国立卫生研究院卒中量表(NIHSS)评分。结果治疗48 h和7 d后,两组PAF、PF4、β-TG及CD62p水平均低于治疗前,且亚低温治疗组低于常规治疗组,差异均有统计学意义(P<0.05)。治疗48 h和7 d后,两组NIHSS评分均低于治疗前,且亚低温治疗组低于常规治疗组,差异均有统计学意义(P<0.05)。脑梗死后48 h、7 d后PAF、PF4、β-TG、CD62p的表达与NIHSS评分均呈正相关。结论急性大面积脑梗死患者在采取局部亚低温疗法治疗后取得了良好的治疗效果,能促进患者神经功能恢复,降低PAF、PF4、β-TG、CD62p的活性,值得临床推广应用。Objective To investigate the clinical effect of local mild hypothermia in patients with acute massive cerebral infarction and the changes of serum platelet activating factors levels of PAF,PF4,β-TG and CD62p before and after the treatment.Methods A total of 100 patients with acute massive cerebral infarction admitted to the Department of Neurology,Haikou Hospital Affiliated to Xiangya Medical College,Central South University from February 2013 to June 2014 were included as the research objects and divided into the conventional treatment group and the local mild hypothermia treatment group with 50 cases in each group according to the random number table method.The patients in the routine treatment group were treated with routine therapy,and the patients in the local mild hypothermia treatment group were treated with local mild hypothermia brain protector on the basis of the routine treatment group.The platelet activators PAF,PF4,β-TG,CD62p levels and NIHSS scores before treatment,48 hours and 7 days after treatment were compared between two groups.Results After 48 hours and 7 days of treatment,PAF,PF4,β-TG and CD62p levels of the two groups were lower than those before treatment,and the mild hypothermia treatment group were lower than the conventional treatment group,and the differences were statistically significant(P<0.05).After 48 hours and 7 days of treatment,the NIHSS scores of the two groups were lower than those before treatment,and the mild hypothermia treatment group was lower than that of the conventional treatment group,and the differences were statistically significant(P<0.05).After cerebral infarction with 48 hours and 7 days,PAF,PF4,β-TG and CD62p were positively correlated with NIHSS score. Conclusion After local mild hypothermia treatment,patients with acute massive cerebralinfarction had achieved good therapeutic effect,which could promote the recovery of patients' neurologicalfunction and reduce the activities of PAF,PF4,β-TG and CD62p,which was worthy of clinical promotionand application.

关 键 词：急性大面积脑梗死 亚低温疗法 血小板活化因子 神经功能评分 

分 类 号：R4[医药卫生—临床医学]