药物干预对妊娠期肾绞痛影响的Meta分析  

A Meta-analysis on the effect of drug intervention on renal colic during pregnancy

作　　者：马寅锐 李赛男[2] 孙洵[1] MA Yin-rui;LI Sai-nan;SUN Xun(Department of Urology,The First People’s Hospital of Kunming,Kunming Yunnan 650051,China;Department of Obstetrics,The First Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]昆明市第一人民医院甘美医院泌尿外科,云南昆明650051 [2]昆明医科大学第一附属医院产科,云南昆明650032

出　　处：《云南医药》2022年第4期22-27,共6页Medicine and Pharmacy of Yunnan

基　　金：昆明市卫生科技人才培养“十工程”资助项目(2020-SW(国)-06)。

摘　　要：目的通过系统评价探讨药物干预治疗妊娠期肾绞痛的临床疗效及安全性。方法检索2021年8月前发表在中文数据库(CBM、CNKI、VIP和万方医学数据库)和英文数据库(PubMed、Cochrane Library、EMbase)的相关文献,收集药物干预治疗妊娠期肾绞痛的随机对照试验研究(RCT),质量评价利用Cochrane系统评价手册5.1版本完成,数据的荟萃分析应用Revman Manager 5.3软件进行。结果共纳入符合标准的文献14篇,包括869例患者。Meta分析显示,与对照组相比,药物治疗的疼痛缓解总有效率较高(RR=1.2779,95%CI[1.1923;1.3697],z=6.93,P<0.0001),且可降低VAS评分(MD=-0.9335,95%CI[-1.1686;-0.6984],P<0.0001)、疼痛再发率(RR=0.4396,95%CI[0.2180;0.8863],z=-2.30,P=0.0004)。不良反应率(RR=0.1930,95%CI[0.1379;0.2701],z=-9.59,P<0.0001)。结论药物干预妊娠期肾绞痛,具有疗效显著、复发率较低、不良反应较少的优势,适合临床实践应用。Objective To explore the clinical efficacy and safety of drug intervention in the treatment of renal colic during pregnancy through system assessment.Methods Relevant literature published in Chinese databases(China biomedical literature database(CBM),China Knowledge Network(CNKI),VIP and Wanfang medical databases)and English databases(PubMed,Cochrane Library and EMBASE)before August 2021 were searched,the randomized controlled trial(RCT)of drug intervention in the treatment of renal colic during pregnancy was collected.The quality evaluation was completed by Cochrane system evaluation manual version 5.1.The meta-analysis of the data was carried out by Revman manager 5.3 software.Results A total of 14 literature meeting the criteria were included in this study,including 869 patients.The results of meta-analysis showed that the total effective rate of pain relief in drug treatment was higher than that in the control group(RR=1.2779,95%CI[1.1923;1.3697],z=6.93,P-value<0.0001),and can reduce the VAS score after treatment(MD=-0.9335,95%CI[-1.1686;-0.6984],P<0.0001),the recurrence rate of pain after intervention was reduced(RR=0.4396,95%CI[0.2180;0.8863],z=-2.30,P-value=0.0004)。The adverse reaction rate was low after drug treatment(RR=0.1930,95%CI[0.1379;0.2701],z=-9.59,P-value<0.0001).Conclusion Drug intervention of renal colic in pregnancy has the advantages of significant curative effect,low recurrence rate and less adverse reactions.It is suitable for clinical practice.

关 键 词：妊娠 肾绞痛 药物 META分析 

分 类 号：R692[医药卫生—泌尿科学]