骨质疏松症与冠状动脉钙化相关性的Meta分析  

Association Between Osteoporosis and Coronary Artery Calcification:a Meta-analysis

作　　者：刘梦苑 郎欣月 杨进刚[1] 胡奉环[1] 吴永健[1] 杨跃进[1] 高晓津[1] LIU Mengyuan;LANG Xinyue;YANG Jingang;HU Fenghuan;WU Yongjain;YANG Yuejin;GAO Xiaojin(Coronary Heart Disease Center,National Center for Cardiovascualr Diseases and Fuwai Hospital,CAMS and PUMC,Beijing(100037,)China)

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院冠心病中心,北京市100037 [2]中国医学科学院北京协和医学院国家心血管病中心阜外医院医学统计部,北京市100037

出　　处：《中国循环杂志》2022年第8期810-816,共7页Chinese Circulation Journal

基　　金：中国医学科学院医学与健康科技创新工程项目(2020-I2M-C&T-B-050)。

摘　　要：目的:利用Meta分析探讨骨质疏松症与冠状动脉钙化(CAC)的相关性。方法:系统性检索Medline、Embase和Cochrane Library数据库中探讨骨质疏松症与CAC相关性的临床研究,依照纳入标准仔细筛选、评估文献。采用随机效应模型计算汇总数据的OR和95%CI来评估骨质疏松症与CAC的相关性。根据性别、骨质疏松症诊断部位进行亚组分析。结果:共纳入8项横断面研究、5946例受试者,其中558例(9.4%)诊断为骨质疏松症,1773例(29.8%)存在CAC。Meta分析结果显示,骨质疏松症与CAC显著相关(OR=1.71,95%CI:1.29~2.25,P<0.001),且在不同诊断部位亚组中均如此(腰椎亚组:OR=2.35,95%CI:1.59~3.48,P<0.001;腰椎或股骨近端亚组:OR=1.48,95%CI:1.03~2.13,P=0.036)。在女性亚组中,骨质疏松症对CAC的影响更显著(OR=2.31,95%CI:1.78~3.00,P<0.001),但在男性亚组中两者无明显关联(OR=1.48,95%CI:0.28~7.74,P=0.645)。结论:骨质疏松症与CAC显著相关,女性骨质疏松症患者和腰椎骨质疏松症患者具有更高的CAC风险。Objectives:To explore the correlation between osteoporosis and coronary artery calcification(CAC)by a meta-analysis.Methods:Medline,Embase,and Cochrane Library databases were searched systematically for clinical studies investigating the relationship between osteoporosis and CAC.The retrieved literature was carefully reviewed and assessed according to the inclusion criteria.The pooled OR and 95%CI were calculated by random effect model to evaluate the correlation between osteoporosis and CAC.Subgroup analyses were performed according to sex and diagnostic site of osteoporosis.Results:Eight cross-sectional studies with 5946 subjects were included in this meta-analysis.558 subjects(9.4%)were diagnosed with osteoporosis and 1773 subjects(29.8%)were diagnosed with CAC.Osteoporosis was significantly associated with the presence of CAC(OR=1.71,95%CI:1.29-2.25,P<0.001).The association was also significant in subgroups of different diagnostic sites(at the lumbar spine:OR=2.35,95%CI:1.59-3.48,P<0.001;at the lumbar spine or the proximal femur:OR=1.48,95%CI:1.03-2.13,P=0.036).The effect of osteoporosis on CAC was more pronounced(OR=2.31,95%CI:1.78-3.00,P<0.001)in the female subgroup,but not in the male subgroup(OR=1.48,95%CI:0.28-7.74,P=0.645).Conclusions:There is a significant correlation between osteoporosis and CAC,and women with osteoporosis and those with lumbar osteoporosis face a higher risk of CAC.

关 键 词：骨质疏松症 骨密度 冠状动脉钙化 META分析 

分 类 号：R54[医药卫生—心血管疾病]