中医药治疗腹膜透析相关性腹膜纤维化实验研究进展  

Experimental research advances of treating peritoneal dialysis-related peritoneal fibrosis with traditionalChinese medicine

作　　者：刘前程 刘鑫 吴敏华 周少华 孟立锋[1,2] Liu Qian-cheng;Liu Xin;Wu Min-hua;Zhou Shao-hua;Meng Li-feng(Guangxi University of Traditional Chinese Medicine,Nanning 530023,China;Department of Nephrology,First Affiliated Hospital,Guangxi University of Traditional Chinese Medicine,Nanning 530023,China)

机构地区：[1]广西中医药大学,南宁530023 [2]广西中医药大学第一附属医院肾内科,南宁530023

出　　处：《临床肾脏病杂志》2022年第7期601-605,共5页Journal Of Clinical Nephrology

基　　金：国家自然科学基金(81860838);广西自然科学基金(2017JJA140363y,2020JJA140292)。

摘　　要：腹膜纤维化是腹膜透析患者腹膜病变最常见的一种类型,主要以细胞外基质蛋白的异常产生、腹膜间质层结缔组织增厚、腹膜间皮细胞损伤以及新生血管形成为特点,目前缺乏有效的防治措施。中医药防治腹膜纤维化具有独特的优势,临床疗效较好,在实验研究方面也取得了一定的进展。本文将从腹膜纤维化动物模型造模方法、单味中药、中药复方及针灸在腹膜纤维化治疗中的实验研究进展做一综述,以期为临床上运用中医药防治腹膜透析相关性腹膜纤维化提供基础理论指导。Peritoneal fibrosis is the most common type of peritoneal lesions in peritoneal dialysis(PD)patients.It is characterized by abnormal production of extracellular matrix protein,thickening of peritoneal interstitial connective tissue,damage of peritoneal mesothelial cells and neovascularization.Currently there is no effective therapy.Traditional Chinese medicine offers unique advantages in the prevention and treatment of peritoneal fibrosis.With an excellent clinical efficacy,it has demonstrated some promising results of experimental research.This review summarized the latest advances of animal models,single/compound herbal medications and acupuncture in the treatment of PD.It provided basic theoretical guidance for clinical application of Chinese medicine in the prevention and treatment of PD-related peritoneal fibrosis.

关 键 词：腹膜透析 腹膜纤维化 模型 动物 中医药治疗 实验研究 

分 类 号：R277.5[医药卫生—中医学]