脂肪源性干细胞来源外泌体在特发性肺纤维化中作用机制的研究进展  

Role of ADSCs-derived exosomes in idiopathic pulmonary fibrosis

作　　者：汪望佳 王敏[1] 李翅翅[2] 张丹[1] WANG Wang-jia;WANG Min;LI Chi-chi;ZHANG Dan(Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China;Department of Plastic Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China.)

机构地区：[1]温州医科大学附属第一医院呼吸与危重症医学科,浙江温州325000 [2]温州医科大学附属第一医院整形外科,浙江温州325000

出　　处：《中国病理生理杂志》2022年第8期1514-1519,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81800075)。

摘　　要：特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种持续进展的间质性肺病,患者通常以进行性呼吸困难和干咳为主要临床症状,临床确诊后中位生存期仅为3~5年[1]。IPF的病因尚不明确,但研究证实持续的炎症反应及上皮-间充质转化(epithelial-mesenchymal transition,EMT)过程与IPF的发生发展关系密切,应用激素、免疫抑制剂及抗EMT过程的药物在临床上发挥了一定的治疗效果,然而这些药物的使用存在其局限性。目前最有效的治疗手段仍是肺移植,却受限于转诊时机的确定和移植后的低存活率。因此进一步研究IPF的发生发展机制并寻求新的治疗靶点具有重大的临床意义。Idiopathic pulmonary fibrosis(IPF)is a interstitial lung disease without effective treatment. It can cause serious long-term disability and early death. Adipose-derived stem cells(ADSCs)have multiple differentiation potentials,and play a therapeutic role in tissue damage and repair through their paracrine function. As an important part of paracrine,exosomes are thought to exert similar biological functions as ADSCs. This paper reviews the role of ADSCs-derived exosomes in IPF in recent years.

关 键 词：外泌体 脂肪源性干细胞 特发性肺纤维化 上皮-间充质转化 免疫调节 

分 类 号：R563[医药卫生—呼吸系统] R363[医药卫生—内科学]