2020—2021年浙江省台州市急性呼吸道感染病原学研究  

Etiological analysis of acute respiratory tract infection in Taizhou of Zhejiang Province from 2020 to 2021

作　　者：王紫怡 翁坚[1] 王红珠 盛莹[1] 李桂霞[1] 陈喜凯[1] 李聪聪 管雅雅 盛盈 沈伟伟[1] WANG Ziyi;WENG Jian;WANG Hongzhu;SHENG Ying;LI Guixia;CHEN Xikai;LI Congcong;GUAN Yaya;SHENG Ying;SHEN Weiwei(Taizhou Center for Disease Control and Prevention,Taizhou,Zhejiang 318000,China)

机构地区：[1]台州市疾病预防控制中心,浙江台州318000

出　　处：《上海预防医学》2022年第7期638-641,649,共5页Shanghai Journal of Preventive Medicine

摘　　要：【目的】分析2020—2021年浙江省台州市急性呼吸道感染患者的主要呼吸道病原感染情况,为急性呼吸道感染的预防和诊疗提供参考依据。【方法】采集2020年9月—2021年8月期间台州2家流感哨点监测医院2831例急性呼吸道感染患者的咽拭子标本,采用多重荧光定量聚合酶链式反应(Multi⁃PCR)对标本进行22种呼吸道病原的检测。【结果】2831份标本病原的总阳性率为14.13%,其中以肠道病毒(7.77%)和呼吸道合胞病毒(1.59%)检出为主。除肠道病毒外,不同性别病原阳性率差异无统计学意义(P>0.05)。不同年龄段患者的病原阳性率差异有统计学意义(P<0.05),其中0~4岁患者的阳性率最高(35.21%)。不同季节就诊患者的病原阳性率差异也有统计学意义(P<0.05),其中夏季就诊患者的阳性率最高(20.54%)。【结论】呼吸道病原感染阳性率较新冠疫情暴发之前有明显下降,在不同年龄段和季节的分布差异具有统计学意义。诊疗前综合考虑不同影响因素以及采用Multi⁃PCR方法,有利于在感染早期更快速有效地检出病原,为台州地区新冠疫情常态化防控形式下的急性呼吸道感染诊治,提供一定的支持和帮助。[Objective]We examined the principal respiratory pathogens in patients with acute respiratory tract infection in Taizhou,Zhejiang Province during 2020‒2021 to provide evidence for prevention,diagnosis and treatment of acute respiratory tract infection.[Methods]From September 2020 to August 2021,a total of 2831 cases with acute respiratory tract infection were collected from two influenza sentinel surveillance hospitals in Taizhou,which had then received the examination of 22 respiratory pathogens by multiple fluorescence quantitative PCR.[Results]The total positive rate of respiratory pathogens in 2831 samples was 14.13%,among which enterovirus(7.77%)and respiratory syncytial virus(1.59%)were the principal pathogens.Except enterovirus,there was no significant difference in the positive rate of pathogens detected by gender(P>0.05).Moreover,there was significant difference in pathogens by age(P<0.05),with the highest positive rate in 0‒4 years(35.21%).There was also significant difference in pathogens by seasons(P<0.05),with the highest positive rate in summer(20.54%).[Conclusion]The positive rate of acute respiratory tract infection decreases significantly,compared with that before the COVID-19 epidemic.The differences in the positive rate differ significantly by age and seasons.Comprehensive consideration of diverse factors before diagnosis and the utilization of multiple fluorescent quantitative PCR can quickly and effectively determine the pathogens in the early stage of infection.Our findings may provide certain support for the diagnosis and treatment of acute respiratory infections in the context of COVID-19 in Taizhou.

关 键 词：急性呼吸道感染 病原学研究 呼吸道病毒 多重荧光定量聚合酶链式反应 

分 类 号：R446.5[医药卫生—诊断学]