严重HIV相关弥漫性白质异常区的短回波时间质子磁共振波谱研究  

Short Echo Time Proton Magnetic Resonance Spectroscopy of Regions of Severe HIV Associated Diffuse White Matter Abnormalities

作　　者：郭小芳 王克刚 GUO Xiao-fang;WANG Ke-gang(Department of Radiology,the Second People's Hospital of Xinxiang,Xinxiang 453000,Henan Province,China;Department of Imaging,the Fifth People's Hospital of Pingtop Mountain,Pingdingshan 450000,Henan,China)

机构地区：[1]新乡市第二人民医院放射科,河南新乡453000 [2]平顶山市第五人民医院影像科,河南平顶山450000

出　　处：《罕少疾病杂志》2022年第9期17-19,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的分析严重人类免疫缺陷病毒(HIV)相关弥漫性白质异常区的短回波时间质子磁共振波普情况。方法选择本院收治的20例严重HIV相关弥漫性白质异常区病患为实验组,2020年3月研究开始,并于2021年3月完成。另选择同时期在本院实施健康体检的20例体检者为常规组。回顾性分析所有人员临床资料,其在进入医院后均开展二维多体素点分辨波谱检查,测量两侧额叶白质和豆状核N-乙酰天门冬氨酸、N-乙酰天门冬氨酸/肌酸、胆碱、相应波谱曲线。对比两组两侧豆状核以及额叶白质N-乙酰天门冬氨酸、N-乙酰天门冬氨酸/肌酸、胆碱水平差异。结果在左侧豆状核方面,实验组N-乙酰天门冬氨酸水平低于常规组;在右侧豆状核方面,实验组N-乙酰天门冬氨酸以及胆碱水平均低于常规组(P<0.05)。在左侧额叶白质方面,实验组N-乙酰天门冬氨酸以及N-乙酰天门冬氨酸/肌酸水平均低于常规组;在右侧额叶白质方面,实验组N-乙酰天门冬氨酸以及N-乙酰天门冬氨酸/肌酸水平均低于常规组(P<0.05)。结论严重HIV相关弥漫性白质异常区者开展短回波时间质子磁共振波谱检查,能够有效诊断疾病。Objective To analyze the short echo time proton magnetic resonance waveforms in severe human immunodeficiency virus(HIV)-associated diffuse white matter abnormal regions.Methods 20 patients with severe HIV associated diffuse white matter abnormal regions admitted to our hospital were selected as the experimental group,and the study started in March 2020 and was completed in March 2021.Another 20 physical examiners who implemented health examination in our hospital during the same period were selected as the routine group.Two dimensional multi voxel point resolved spectroscopy was performed on all individuals retrospectively with clinical data on their entry to the hospital,measuring N-acetylaspartate,N-acetylaspartate/creatine,choline,and corresponding spectral profiles in the frontal white matter and lentiform nucleus bilaterally.Differences in the levels of N-acetylaspartate,N-acetylaspartate/creatine,and choline in the lentiform nucleus as well as in the frontal white matter between the two groups were compared.Results with respect to the left lentiform nucleus,the level of N-acetylaspartate in the experimental group was lower than that in the conventional group;In terms of the right lentiform nucleus,the levels of N-acetylaspartate as well as choline in the experimental group were lower than those in the conventional group(P<0.05).In terms of the left frontal white matter,the levels of N-acetylaspartate as well as N-acetylaspartate/creatine in the experimental group were lower than those in the conventional group;In terms of the right frontal white matter,the levels of N-acetylaspartate as well as N-acetylaspartate/creatine in the experimental group were lower than those in the conventional group(P<0.05).Conclusions The development of short echo time proton magnetic resonance spectroscopy in patients with areas of severe HIV associated diffuse white matter abnormalities enables effective diagnosis of disease.

关 键 词：质子磁共振波谱 短回波时间 弥漫性白质异常区 人类免疫缺陷病毒 胆碱 

分 类 号：R445.2[医药卫生—影像医学与核医学]