基于“阳郁血瘀”理论探讨益气通脉煎剂治疗老年病态窦房结综合征的临床疗效  

Based on the Theory of"Yang Depression and Blood Stasis"to Explore the Clinical Efficacy of Yiqi Tongmai Decoction in the Treatment of Sick Sinus Syndrome in the Elderly

作　　者：李祥[1] 袁利梅[2] 牛媛媛[3] 刘磊[4] LI Xiang;YUAN Li-mei;NIU Yuan-yuan;LIU Lei(Department of Emergency Internal Medicine,The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Henan Province,China;Cardiovascular Ward 1,The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Henan Province,China;The Second Cardiovascular Ward of the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Henan Province,China;The First Ward of Geriatrics,The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Henan Province,China)

机构地区：[1]河南中医药大学第三附属医院急诊内内科,河南郑州450000 [2]河南中医药大学第三附属医院心血管一病区,河南郑州450000 [3]河南中医药大学第三附属医院心血管二病区,河南郑州450000 [4]河南中医药大学第三附属医院老年病一病区,河南郑州450000

出　　处：《罕少疾病杂志》2022年第9期34-36,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨基于“阳郁血瘀”理论探讨益气通脉煎剂治疗老年病态窦房结综合征(简称“病窦”)的临床疗效。方法选定本院2019年4月至2021年4月收诊的104例老年病窦患者,分层随机法分为试验组(52例,常规西药+益气通脉煎剂)与对照组(52例,常规西药)2组。评测两组治疗4周后的乏力、形寒肢冷、头晕、心悸不安中医证候积分,比较两组的窦房传导时间(SACT)、校正窦房结恢复时间(CSNRT)、窦房结恢复时间(SNRT),分析其超敏C反应蛋白(hs-CRP)、N末端B型钠尿肽前体(NT-proBNP)水平,并统计其不良反应发生率。结果⑴试验组治疗后的乏力、形寒肢冷、头晕、心悸不安中医证候积分均较对照组低,差异有统计学意义(P<0.05)。⑵试验组治疗后的SACT、CSNRT、SNRT均较对照组低,差异有统计学意义(P<0.05)。⑶试验组治疗后的hs-CRP、NT-prBNP均较对照组低,差异有统计学意义(P<0.05)。⑷试验组胃部不适、口干、心率加快的发生率与对照组比较,差异无统计学意义(P>0.05)。结论基于“阳郁血瘀”理论采用益气通脉煎剂对老年病窦患者进行治疗,有助于改善其临床各项症状及窦房结功能,减轻其炎症反应,且不良反应较少。Objective To explore the clinical efficacy of Yiqi Tongmai Decoction in the treatment of sick sinus syndrome(abbreviated as"sick sinus")in the elderly based on the theory of"yang depression and blood stasis".Methods A total of 104 elderly sick sinus patients admitted to our hospital from April 2019 to April 2021 were selected and randomly divided into experimental group(52 cases,conventional western medicine+Yiqi Tongmai decoction)and control group(52 cases,conventional western medicine)2 groups.The scores of TCM syndromes of fatigue,cold limbs,dizziness,and palpitations in the two groups after 4 weeks of treatment were evaluated,and the sinus conduction time(SACT),corrected sinus node recovery time(CSNRT),and sinus node recovery time(SNRT)of the two groups were compared.Analyze its hypersensitive C-reactive protein(hs-CRP),N-terminal B-type natriuretic peptide precursor(NT-proBNP)levels,and count the incidence of adverse reactions.Results(1)The scores of TCM syndromes of fatigue,cold limbs,dizziness,and palpitations in the experimental group after treatment were lower than those in the control group,and the difference was statistically significant(P<0.05).(2)SACT,CSNRT and SNRT of the experimental group after treatment were lower than those of the control group,and the difference was statistically significant(P<0.05).(3)The hs-CRP and NT-prBNP of the experimental group after treatment were lower than those of the control group,and the difference was statistically significant(P<0.05).(4)Compared with the control group,the incidence of stomach discomfort,dry mouth,and increased heart rate in the experimental group was not statistically different(P>0.05).Conclusion Based on the theory of"yang depression and blood stasis",the use of Yiqi Tongmai decoction to treat elderly patients with sick sinus can help improve their clinical symptoms and sinus node function,reduce their inflammation,and have fewer adverse reactions.

关 键 词：病态窦房结综合征 老年 益气通脉煎剂 阳郁血瘀 安全性 

分 类 号：R541.4[医药卫生—心血管疾病]