新型一氧化氮生物医学传感功能材料的制备及表征  

Preparation and characterization of novel functional materials for biomedical sensing nitric oxide

作　　者：陈道明 郑霄 刘晓军[1] 朱春楠[1] 刘超 郑冬云[1] CHEN Daoming;ZHENG Xiao;LIU Xiaojun;ZHU Chunnan;LIU Chao;ZHENG Dongyun(College of Biomedical Engineering&Key Laboratory of Cognitive Science of State Ethnic Affairs Commission&Hubei Key Laboratory of Medical Information Analysis&Tumor Diagnosis and Treatment,South-Central Minzu University,Wuhan 430074,China)

机构地区：[1]中南民族大学生物医学工程学院&脑认知国家民委重点实验室&医学信息分析及肿瘤诊疗湖北省重点实验室,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2022年第5期565-572,共8页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家自然科学基金资助项目(22004134);国家留学基金委资助项目(201807780004);湖北省自然科学基金资助项目(2020CFB313);中央高校基本科研业务费专项资金资助项目(CZQ21025)。

摘　　要：借助于电化学沉积法和二步电聚合法,制得了金纳米颗粒-聚灿烂甲酚蓝纳米复合膜,并将其固定于玻碳电极表面.利用扫描电子显微镜技术,对纳米复合膜的表面形貌进行了表征.电化学试验显示:该纳米复合物对一氧化氮的电化学氧化具有明显的催化作用.纳米复合膜呈三维多孔结构,修饰电极具有较大的比表面积,有助于一氧化氮在电极表面的富集.电化学交流阻抗谱学表征表明:纳米复合膜修饰玻碳电极具有较小的界面电阻,有利于加快一氧化氮与电极之间的电子传递.该纳米复合膜制备方法简单可控,纳米复合物对一氧化氮氧化的电催化效应明显,有望在一氧化氮生物医学传感发挥作用.By means of electrochemical deposition and two-step electropolymerization,gold nanoparticles and poly(brilliant cresyl blue)nanocomposite film was synthesized on the surface of glassy carbon electrode.Scanning electron microscopy was used to characterize the surface morphology of the nanocomposite film.Electrochemical testing showed that the nanocomposite had obvious catalytic effect on the electrochemical oxidation of nitric oxide.The nanocomposite film had a three-dimensional porous structure with the large specific surface area of modified electrode,thus was conducive to the enrichment of nitric oxide on the electrode surface.Electrochemical impedance spectroscopy characterization showed that the nanocomposite film modified glassy carbon electrode had low interface resistance,which helped to speed up the electron transfer between the nitric oxide and the electrode.In conclusion,a simple and controllable fabrication process for Au/poly(brilliant cresyl blue)nanocomposite was developed.The nanocomposite showed good electrocatalytic effect to the oxidation of nitric oxide and may be applied in nitric oxide biomedical sensing.

关 键 词：金纳米颗粒 聚灿烂甲酚蓝 纳米复合物 一氧化氮 生物医学传感 

分 类 号：O657.1[理学—分析化学]