丙烯醇反马氏水合制备1,3-丙二醇  

Preparation of 1,3-Propanediol by Anti-Markovnikov Hydration of Allyl Alcohol

作　　者：贾瑞龙 秦晓瑶[1] 华其灼灼 刘雷 Jia Ruilong;Qin Xiaoyao;Hua Qizhuozhuo;Liu Lei(College of Chinese Medicine and Food Engineering,Shanxi University of Chinese Medicine,Jinzhong,030619;College of Chemistry and Chemical Engineering,Taiyuan University of Technology,Taiyuan,030024)

机构地区：[1]山西中医药大学中药与食品工程学院,晋中030619 [2]太原理工大学化学化工学院,太原030024

出　　处：《化学通报》2022年第8期976-980,共5页Chemistry

基　　金：国家自然科学基金项目(U1910202,21978194);山西中医药大学博士科研启动基金项目(2020BKS05,2020BK14);山西中医药大学中药学科建设项目(1008Z3)资助。

摘　　要：1,3-丙二醇具有很高的经济价值,是合成聚对苯二甲酸丙二酯的重要原料。基于甘油甲酸介入法获得的丙烯醇作为平台分子,通过丙烯醇与TiCl_(4)-NaBH_(4)反应,首次实现常温常压下1,3-丙二醇的制备,为1,3-丙二醇的合成提供了一条新的路径。在优化条件下,1,3-丙二醇的产率68.73%。推测反应机理为,TiCl_(4)和NaBH_(4)发生反应,生成中间体“BH_(3)”,进而实现了丙烯醇反马氏水合制备1,3-丙二醇。1,3-Propanediol as an important polypropylene terephthalate raw material has high economic value.The allyl alcohol prepared by formic acid mediated deoxydehydratation of glycerol was used as a platform molecule,and it was reacted with TiCl_(4)-NaBH_(4)at room temperature to realize the preparation of 1,3-propanediol,which provided a new path for the synthesis of 1,3-propanediol.Under the optimal conditions,the yield of 1,3-propanediol was 68.76%.It was speculated that the reaction mechanism was as follows:TiCl_(4)reacted with NaBH_(4)to generate intermediate‘BH_(3)’,and then preparation of 1,3-propanediol by anti-Markovnikov hydration of allyl alcohol was realized.

关 键 词：甘油 丙烯醇 1 3-丙二醇 反马氏水合反应 

分 类 号：TQ223.162[化学工程—有机化工]