中、重度卵巢过度刺激综合征患者取卵与解冻移植间隔时间对妊娠结局的影响  

Effect of different intervals between oocyte retrieval and frozen-thawed embryo transfer in pregnancy outcome in patients with moderate and severe ovarian hyperstimulation syndrome

作　　者：段海霞 师娟子 范丽娟 Duan Haixia;Shi Juanzi;Fan Lijuan(The Fifth Gynecology Department,Northwest Women's&Children's Hospital,Xi'an 710000,China;The ART Center,Northwest Women's&Children's Hospital,Xi'an 710000,China)

机构地区：[1]西北妇女儿童医院生殖妇科,西安710000 [2]西北妇女儿童医院生殖中心,西安710000

出　　处：《中华生殖与避孕杂志》2022年第7期724-728,共5页Chinese Journal of Reproduction and Contraception

摘　　要：目的探讨中、重度卵巢过度刺激综合征患者取卵术后最佳解冻移植时间。方法回顾性队列研究分析2017年1月至2019年12月期间在西北妇女儿童医院生殖中心第一次行取卵术且术后因中、重度卵巢过度刺激综合征行全胚冷冻患者的临床资料。按取卵术与解冻移植间隔时间分为3组,A组:间隔1个月;B组:间隔2个月;C组:间隔≥3个月。主要观察指标为活产率,次要观察指标为生化妊娠率、临床妊娠率、胚胎种植率、异位妊娠率、流产率、早产率及出生缺陷率。采用卡方检验比较各项指标组间差异。结果B组活产率为70.27%(26/37),高于A组[58.62%(17/29)]和C组[52.27%(23/44)],但三组间比较差异无统计学意义(P=0.667);A组流产率[0%(0/18)]显著低于C组[25.81%(8/31),P=0.017];三组间生化妊娠率、临床妊娠率、胚胎种植率、异位妊娠率、早产率及出生缺陷率组间比较差异均无统计学意义(均P>0.05)。结论中、重度卵巢过度刺激综合征患者取卵术后解冻移植间隔时间对妊娠结局无影响。Objective To investigate the pregnancy outcomes of different intervals between oocyte retrieval and frozen-thawed embryo transfer(FET)in moderate and severe ovarian hyperstimulation syndrome(OHSS)patients.Methods Clinical data of infertile patients who underwent their first in vitro fertilization-embryo transfer(IVF-ET)and froze all their embryos for moderate or severe OHSS from January 2017 to December 2018 in the ART Center,Northwest Women's&Children's Hospital were analyzed retrospectively.All patients were divided into three groups according to the interval between oocyte retrieval and FET.Group A:one month interval;group B:two months interval;group C:the interval was three months or above.Main outcome was live birth rate;secondary outcomes included biochemical pregnancy rate,clinical pregnancy rate,implantation rate,ectopic pregnancy rate,miscarriage rate,preterm birth rate and birth defect rate.Chi square test was performed to compare the differences of the outcomes among the three groups.Results The live birth rate of group B[70.27%(26/37)]was higher than that of group A[58.62%(17/29)]and group C[52.27%(23/44)],but the difference was not statistically significant(P=0.667).The miscarriage rate of group A[0%(0/18)]was significantly lower than that of group C[25.81%(8/31),P=0.017].There were no significant differences among the three groups in biochemical pregnancy rate,implantation rate,ectopic pregnancy rate,preterm birth rate and birth defect rate(all P>0.05).Conclusion The interval between oocyte retrieval and FET in moderate and severe OHSS patients does not impact pregnancy outcome.

关 键 词：受精 体外 胚胎移植 卵巢过度刺激综合征 解冻移植 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]