宫腔液细胞外囊泡在子宫内膜容受性中的研究进展  

Research progress of uterine fluid extracellular vesicles in endometrial receptivity

作　　者：任雨蒙 韩红敬[1] Ren Yumeng;Han Hongjing(Reproductive Center of Peking University People's Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院生殖医学中心,北京100044

出　　处：《中华生殖与避孕杂志》2022年第7期746-750,共5页Chinese Journal of Reproduction and Contraception

摘　　要：子宫内膜容受性是指子宫内膜允许囊胚定位、黏附、穿透、植入从而促进胚胎着床、发育的能力。种植期子宫内膜的特征以及子宫内膜容受性标志物一直以来都是研究热点,尽管已经取得了较大进展,但仍缺乏公认的预测临床妊娠的标志物。已有研究显示,抽吸宫腔液对胚胎种植过程没有负面影响,宫腔液检查可作为无创检测的一种手段;同时宫腔液中含有细胞外囊泡,细胞外囊泡中miRNA、蛋白质、DNA及脂质在卵泡发育成熟、胚胎发育及着床等生殖过程中起重要作用,将来有望成为子宫内膜容受性标志物并作为治疗靶点。本文将对宫腔液细胞外囊泡在子宫内膜容受性中的研究进展进行综述。Endometrial receptivity refers to the ability of the endometrium to allow blastocyst location,adhesion,penetration,implantation,and to promote embryo implantation and development.The study of endometrial characteristics during implantation to find markers of endometrial receptivity has long been a hot topic of research.Although progress has been made,there is still a lack of recognized markers for predicting clinical pregnancy.Recent studies have shown that aspiration of uterine fluid has no negative effect on embryo implantation and can be studied as a non-invasive test.At the same time,it was found that there were extracellular vesicles in uterine fluid,in which miRNA,protein,DNA and lipid play an important role in the reproductive process of follicle development and maturation,embryo development and implantation,etc.,and it is expected to be used as endometrial receptivity markers and therapeutic targets in the future.In this article,we will review the research progress of uterine fluid extracellular vesicles in the evaluation of endometrial receptivity.

关 键 词：子宫内膜容受性 宫腔液 细胞外囊泡 胚胎着床 

分 类 号：R711.74[医药卫生—妇产科学]